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Substance Name: Talazoparib [USAN:INN]
RN: 1207456-01-6
UNII: 9QHX048FRV
InChIKey: HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Notes

  • Inhibits both PARP1 and PARP2.
  • NCI: An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. (NCI Thesaurus)

Molecular Formula

  • C19-H14-F2-N6-O

Molecular Weight

  • 380.3566
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
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Names and Synonyms

Name of Substance

  • Talazoparib [USAN:INN]

Synonyms

  • 3H-Pyrido(4,3,2-de)phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)-
  • BMN 673
  • BMN-673
  • BMN673
  • LT-673
  • Talazoparib
  • Talzenna
  • UNII-9QHX048FRV

Registry Numbers

CAS Registry Number

  • 1207456-01-6

FDA UNII

  • 9QHX048FRV

System Generated Number

  • 1207456016

Structure Descriptors

InChI

InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1

InChIKey

HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Smiles

Cn1ncnc1[C@@H]2[C@H](Nc3cc(F)cc4C(=O)NN=C2c34)c5ccc(F)cc5