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Substance Name: Roxarsone [USAN:USP:INN:BAN]
RN: 121-19-7
UNII: H5GU9YQL7L
InChIKey: XMVJITFPVVRMHC-UHFFFAOYSA-N

Note

  • An arsenic derivative which has anticoccidial action and promotes growth in animals.

Molecular Formula

  • C6-H6-As-N-O6

Molecular Weight

  • 263.0364
 

Classification Codes

  • Agricultural Chemical
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Coccidiostats
  • Growth Regulator / Fertilizer
  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • 3-Nitro-4-hydroxyphenylarsonic acid
  • Roxarsone
  • Roxarsone [USAN:USP:INN:BAN]

MeSH Heading

  • Roxarsone

Synonyms

  • 2-Nitro-1-hydroxybenzene-4-arsonic acid
  • 3-Nitro
  • 3-Nitro-10
  • 3-Nitro-20
  • 3-Nitro-4-hydroxybenzenearsonic acid
  • 3-Nitro-4-hydroxyphenylarsonic acid
  • 3-Nitro-50
  • 3-Nitro-80
  • 3N4hpa
  • 4-16-00-01188 (Beilstein Handbook Reference)
  • 4-Hydroxy-3-nitrobenzenearsonic acid
  • 4-Hydroxy-3-nitrobenzolarsonsaeure
  • 4-Hydroxy-3-nitrophenylarsonic acid
  • A 19603
  • AI3-16421
  • Aklomix-3
  • Arsonic acid, (4-hydroxy-3-nitrophenyl)-
  • Benzenearsonic acid, 4-hydroxy-3-nitro-
  • BRN 1976533
  • CCRIS 1661
  • EINECS 204-453-7
  • HSDB 4296
  • Kyselina 4-hydroxy-3-nitrofenylarsonova
  • Kyselina 4-hydroxy-3-nitrofenylarsonova [Czech]
  • NCI-C56508
  • NIH 1529
  • Nitro acid 100 per cent
  • Nitrophenolarsonic acid
  • NSC 2101
  • NSC-2101
  • Ren O-sal
  • Ren-O-sal
  • Ristat
  • Roxarson
  • Roxarson [INN-Spanish]
  • Roxarsone
  • Roxarsonum
  • Roxarsonum [INN-Latin]
  • UNII-H5GU9YQL7L

Systematic Names

  • Arsonic acid, (4-hydroxy-3-nitrophenyl)-
  • Arsonic acid, As-(4-hydroxy-3-nitrophenyl)-
  • Benzenearsonic acid, 4-hydroxy-3-nitro-
  • Roxarsone

Superlist Name

  • Roxarsone

Registry Numbers

CAS Registry Number

  • 121-19-7

FDA UNII

  • H5GU9YQL7L

Other Registry Numbers

  • 8028-22-6
  • 8028-23-7

System Generated Number

  • 0000121197

Structure Descriptors

InChI

1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12)

InChIKey

XMVJITFPVVRMHC-UHFFFAOYSA-N

Smiles

[As](=O)(c1cc([N+](=O)[O-])c(cc1)O)(O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 intraperitoneal 34mg/kg (34mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 5, Pg. 507, 1963.
chicken LD50 oral 110mg/kg (110mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: HEMORRHAGE
Toxicology and Applied Pharmacology. Vol. 5, Pg. 507, 1963.
dog LD50 oral 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

KIDNEY, URETER, AND BLADDER: HEMATURIA
Toxicology and Applied Pharmacology. Vol. 5, Pg. 507, 1963.
mouse LD50 oral 244mg/kg (244mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-345, Pg. 1989,
rat LD50 intraperitoneal 66mg/kg (66mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
Toxicology and Applied Pharmacology. Vol. 5, Pg. 507, 1963.
rat LD50 oral 81mg/kg (81mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-345, Pg. 1989,
turkey LD50 oral 61mg/kg (61mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: HEMORRHAGE
Toxicology and Applied Pharmacology. Vol. 5, Pg. 507, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.050 (none)   EST
Water Solubility 2.22E+04 mg/L 25 EST
Vapor Pressure 2.74E-10 mm Hg 25 EST
Henry's Law Constant 4.28E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.59E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.