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Substance Name: Ribociclib [USAN:INN]
RN: 1211441-98-3
UNII: TK8ERE8P56
InChIKey: RHXHGRAEPCAFML-UHFFFAOYSA-N

Notes

  • Inhibits both CDK4 and CDK6.
  • NCI: An orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. (NCI Thesaurus)

Molecular Formula

  • C23-H30-N8-O

Molecular Weight

  • 434.545
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • Ribociclib [USAN:INN]

Synonyms

  • Kisqali
  • LEE 011
  • LEE-011
  • LEE011
  • LEE011A
  • Ribociclib
  • UNII-TK8ERE8P56

Registry Numbers

CAS Registry Number

  • 1211441-98-3

FDA UNII

  • TK8ERE8P56

System Generated Number

  • 1211441983

Structure Descriptors

InChI

InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)

InChIKey

RHXHGRAEPCAFML-UHFFFAOYSA-N

Smiles

CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N4CCNCC4)nc2n1C5CCCC5