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Substance Name: Filgrastim [USAN:INN:BAN]
RN: 121181-53-1
UNII: PVI5M0M1GW

Notes

  • A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of NEUTROPENIA, and to prepare blood progenitor cells for collection and use in PERIPHERAL BLOOD STEM CELL TRANSPLANTATION.
  • NCI: A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. (NCI Thesaurus)

Molecular Formula

  • C845-H1339-N223-O243-S9

Molecular Weight

  • 18798.7851
 

Classification Codes

  • Antineutropenic
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Hematopoietic Stimulant
  • Human Data
  • Natural Product

Names and Synonyms

Name of Substance

  • Filgrastim
  • Filgrastim [USAN:INN:BAN]

MeSH Heading

  • Filgrastim

Synonyms

  • Biograstim
  • DRG-0086
  • Filgrastim
  • Filgrastim Hexal
  • Filgrastim ratiopharm
  • Filgrastim-sndz
  • Filgrastime
  • Filgrastime [INN-French]
  • Filgrastimum
  • Filgrastimum [INN-Latin]
  • Granulocyte colony stimulating factor, recombinant
  • Granulokine
  • HSDB 8159
  • KRN 8601
  • Leucostim
  • MBRI 9901
  • MK-4214
  • N-L-Methionylcolony-stimulating factor (human clone 1034)
  • Neukine
  • Neupogen
  • Nivestim
  • Nufile-Safe
  • r-metHug-C-SF
  • r-metHug-CSF
  • Ratiograstim
  • Recombinant methionyl granulocyte colony stimulating factor
  • Recombinant methionyl human G-CSF
  • rHG-CSF
  • Tevagrastim
  • UNII-PVI5M0M1GW
  • XM 02
  • Zarxio
  • Zarzio

Systematic Name

  • Colony-stimulating factor (human clone 1034), N-L-methionyl-

Superlist Name

  • Filgrastim

Registry Numbers

CAS Registry Number

  • 121181-53-1

FDA UNII

  • PVI5M0M1GW

System Generated Number

  • 0121181531

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo subcutaneous 3214mg/kg/3D- (3214mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Internal Medicine. Vol. 33, Pg. 641, 1994.
monkey LD50 intravenous > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 intraperitoneal > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 intravenous > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 oral > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 subcutaneous > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 intraperitoneal > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 intravenous > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 oral > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 subcutaneous > 3mg/kg (3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.