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Substance Name: Mephentermine sulfate [USP]
RN: 1212-72-2
UNII: 580655Z8RR
InChIKey: DNKCFBJMFIUNRS-UHFFFAOYSA-N

Note

  • A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Molecular Formulas

  • C11-H17-N.1/2H2-O4-S
  • C22-H34-N2.H2-O4-S

Molecular Weight

  • 424.6024
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Pharmaceutic Aid (Tablet and Capsule Diluent)
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Names and Synonyms

Name of Substance

  • Mephentermine sulfate [USP]

Synonyms

  • EINECS 214-923-3
  • Fentermin
  • Mephentermine sulfate
  • Mephentermine sulphate
  • N,alpha,alpha-Trimethylphenethylamine sulfate (2:1)
  • N-Methyl-omega-phenyl-tert-butylamine
  • UNII-580655Z8RR
  • Wyamine sulfate

Systematic Names

  • Benzeneethanamine, N,alpha,alpha-trimethyl-, sulfate (2:1)
  • Mephentermine sulphate
  • Phenethylamine, N,alpha,alpha-trimethyl-, sulfate (2:1)

Registry Numbers

CAS Registry Number

  • 1212-72-2

FDA UNII

  • 580655Z8RR

Related Registry Number

  • 100-92-5 (Parent)

System Generated Number

  • 0001212722

Molecular Formulas

Molecular Formulas

  • C11-H17-N.1/2H2-O4-S
  • C22-H34-N2.H2-O4-S

Molecular Formula Fragments

  • C11-H17-N
  • C22-H34-N2
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C11H17N.H2O4S/c2*1-11(2,12-3)9-10-7-5-4-6-8-10;1-5(2,3)4/h2*4-8,12H,9H2,1-3H3;(H2,1,2,3,4)

InChIKey

DNKCFBJMFIUNRS-UHFFFAOYSA-N

Smiles

CNC(C)(C)Cc1ccccc1.CNC(C)(C)Cc2ccccc2.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 232mg/kg (232mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: TREMOR
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 705, 1954.
women TDLo oral 500ug/kg/2D-I (0.5mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Acta Clinica Belgica. Vol. 41, Pg. 207, 1986.