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Substance Name: Estrogens, conjugated [USP:JAN]
RN: 12126-59-9
UNII: IU5QR144QX
InChIKey: QTTMOCOWZLSYSV-QWAPEVOJSA-M

Notes

  • A mixture of plant base and synthetic esterified estrogens; has been recalled in 2000.
  • A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.

Molecular Formula

  • Unspecified

Molecular Weight

  • 370.3991
 

Classification Codes

  • Drug / Therapeutic Agent
  • Estrogen
  • Estrogens
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Natural Product
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Estratab
  • Estrogenic Substances, Conjugated
  • Estrogens, conjugated [USP:JAN]

MeSH Heading

  • Estrogens, conjugated

Synonyms

  • Amnestrogen
  • Ayerogen
  • Ayerogen Crema Vaginal
  • Azumon
  • C.E.S.
  • CCRIS 7207
  • CEE
  • Cenestin
  • Climarest
  • Climatrol
  • Climestrone
  • Climopax
  • CO-Estro
  • Conest
  • Conestron
  • Conjes
  • Conjugated equine estrogen
  • Conjugated estrogens
  • Conjugen
  • Conjutabs
  • Dagynil
  • EINECS 235-199-5
  • Emopremarin
  • Equigyne
  • Equin
  • Estratab
  • Estrifol
  • Estroate
  • Estrocon
  • Estrogen
  • Estrogenic substances, cojugated
  • Estrogens conjugated
  • Estrogens conjugated [USP]
  • Estrogens, conjugated
  • Estrogens, conjugated synthetic A
  • Estrogens, conjugates
  • Estromed
  • Estropan
  • Estroplus
  • FEM H
  • Femacoid
  • Femavit
  • Femest
  • Formatrix
  • Ganeake
  • Genisis
  • Glyestrin
  • HSDB 3076
  • Hyphorin
  • Kestrin
  • Mannest
  • Menogen
  • Menopak-E
  • Menoprem Continuous
  • Menotab
  • Menotrol
  • Menpoz
  • Msmed
  • Neo-Menovar
  • Novoconestron
  • Oestrilin
  • Oestro-feminal
  • Oestrogen
  • Oestropak morning
  • Ovest
  • Palopause
  • Par Estro
  • PMB
  • Premaril
  • Premaril Plus
  • Premarin
  • Premarin Crema V
  • Premarin Creme
  • Premarin Vaginal Creme
  • Premarina
  • Premarose
  • Prempak
  • Presomen
  • Prevagin-Premaril
  • Primarin
  • Promarit
  • Provette Continuous
  • Romeda
  • Sefac
  • SK-Estrogens
  • Sodestrin-H
  • Sodium estrone sulfate, mixted with sodium equilin sulfate
  • Srogen
  • Sukingpo
  • TAG-39
  • Theogen
  • Transannon
  • Trocosone
  • UNII-IU5QR144QX
  • Zeste

Systematic Names

  • Conjugated estrogenic hormones
  • Estrogens, conjugates
  • Premarin

Registry Numbers

CAS Registry Number

  • 12126-59-9

FDA UNII

  • IU5QR144QX

System Generated Number

  • 0012126599

Structure Descriptors

InChI

1S/C18H20O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3-5,10,14,16H,2,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,16+,18+;/m1./s1

InChIKey

QTTMOCOWZLSYSV-QWAPEVOJSA-M

Smiles

[Na+].C[C@]12CC[C@H]3C(=CCc4cc(OS(=O)(=O)[O-])ccc34)[C@@H]1CCC2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1740mg/kg (1740mg/kg)   Drugs in Japan Vol. -, Pg. 178, 1990.
rat LD50 intraperitoneal 325mg/kg (325mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.