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Substance Name: Clobutinol hydrochloride [JAN]
RN: 1215-83-4
UNII: N2U6799DZQ
InChIKey: ZMROYCGIWPNZNJ-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C14-H22-Cl-N-O.Cl-H

Molecular Weight

  • 292.248
 
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Names and Synonyms

Name of Substance

  • Clobutinol hydrochloride [JAN]

Synonyms

  • 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol hydrochloride
  • 2-(p-Chlorobenzyl)-3-dimethylaminomethyl-2-butanol hydrochloride
  • 4-Chloro-alpha-(2-(dimethylamino)-1-methylethyl)-alpha-methylbenzeneethanol hydrochloride
  • Biotertussin
  • Clobutinol HCl
  • Clobutinol hydrochloride
  • EINECS 214-931-7
  • KAT 256
  • p-Chloro-alpha-(2-dimethylamino-1-methylethyl)-alpha-methylphenethyl alcohol hydrochloride
  • p-Cloro-alpha-(2-(dimetilamino)-1-metiletil)-alpha-metil fenetil alcool cloridrato
  • p-Cloro-alpha-(2-(dimetilamino)-1-metiletil)-alpha-metil fenetil alcool cloridrato [Italian]
  • Pertoxil
  • Petoxil
  • Silom
  • Silomat
  • UNII-N2U6799DZQ

Systematic Names

  • Benzeneethanol, 4-chloro-alpha-(2-(dimethylamino)-1-methylethyl)-alpha-methyl-, hydrochloride
  • p-Chloro-alpha-(2-(dimethylamino)-1-methylethyl)-alpha-methylphenethyl alcohol hydrochloride
  • Phenethyl alcohol, p-chloro-alpha-(2-(dimethylamino)-1-methylethyl)-alpha-methyl-, HCl

Registry Numbers

CAS Registry Number

  • 1215-83-4

FDA UNII

  • N2U6799DZQ

System Generated Number

  • 0001215834

Molecular Formulas

Molecular Formula

  • C14-H22-Cl-N-O.Cl-H

Molecular Formula Fragments

  • C14-H22-Cl-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H22ClNO.ClH/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12;/h5-8,11,17H,9-10H2,1-4H3;1H

InChIKey

ZMROYCGIWPNZNJ-UHFFFAOYSA-N

Smiles

C(c1ccc(cc1)Cl)[C@@]([C@@H](CN(C)C)C)(O)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 45300ug/kg (45.3mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 961, 1970.
guinea pig LDLo intravenous 17mg/kg (17mg/kg) CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 609, 1988.
mouse LD50 intramuscular 125mg/kg (125mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 149, 1975.
mouse LD50 intraperitoneal 125mg/kg (125mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 intravenous 40900ug/kg (40.9mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 oral 334mg/kg (334mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 subcutaneous 262mg/kg (262mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 961, 1970.
rat LD50 intramuscular 151mg/kg (151mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 149, 1975.
rat LD50 intraperitoneal 151mg/kg (151mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 intravenous 63mg/kg (63mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 oral 802mg/kg (802mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 subcutaneous 702mg/kg (702mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.