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Substance Name: FK 453
RN: 121524-18-3
InChIKey: OPLOPFHUHFGKMJ-JXOMPUQVSA-N

Note

  • Adenosine A1 receptor antagonist; a new antihypertensive agent with diuretic action in isolated rabbit aorta; FR113452 is the S-(-) enantiomer of FK 453.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C23-H25-N3-O2

Molecular Weight

  • 375.47
 
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Names and Synonyms

Name of Substance

  • FK 453

Synonyms

  • (+)-(R)-((E)-3-(2-Phenylpyrazolo(1,5-a)pyridin-3-yl)acryloyl)-2-piperidineethanol
  • (R-(E))-1-(1-Oxo-3-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-2-propenyl)-2-piperidineethanol
  • FK 453

Systematic Name

  • 2-Piperidineethanol, 1-(1-oxo-3-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-2-propenyl)-, (R-(E))-

Registry Numbers

CAS Registry Number

  • 121524-18-3

System Generated Number

  • 0121524183

Structure Descriptors

InChI

1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m1/s1

InChIKey

OPLOPFHUHFGKMJ-JXOMPUQVSA-N

Smiles

N1([C@H](CCCC1)CCO)C(\C=C\c1c(nn2ccccc12)c1ccccc1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD oral > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 46, Pg. 185, 1996.