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Substance Name: Technetium Tc 99m medronate [USP]
RN: 121524-79-6
UNII: X89XV46R07
InChIKey: IUPNVOAUFBLQME-SGNQUONSSA-J

Notes

  • A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
  • A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.

    NCI: technetium Tc 99m methylene diphosphonate A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scinitgraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions. (NCI Thesaurus)

Molecular Formula

  • C-H6-O8-P2-Tc

Molecular Weight

  • 306.9984
 

Classification Codes

  • Diagnostic Aid (Skeletal Imaging)
  • Diagnostic Uses of Chemicals
  • Indicators and Reagents
  • Radioactive Agent
  • Radiopharmaceuticals
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Names and Synonyms

Name of Substance

  • Technetium ((sup 99m)Tc) methylenediphosphonate for injection [JAN]
  • Technetium Tc 99m medronate
  • Technetium Tc 99m medronate [USP]

MeSH Heading

  • Technetium Tc 99m Medronate

Synonyms

  • 99mTc-MDP
  • 99mTc-Methylene Diphosphonate
  • AN-MDP
  • CIS-MDP
  • Draximage MDP-25
  • MDP Kit
  • MDP-BRACCO
  • Osteolite
  • Tc-99 Medronate
  • Tc-99m MDP
  • Tc-99m Methylene Diphosphonate
  • Technescan MDP
  • Technetium ((sup 99m)Tc) Methylenediphosphonate
  • Technetium ((sup 99m)Tc) methylenediphosphonate for injection
  • Technetium Methylene Diphosphonate
  • Technetium Tc 99m medronate
  • Technetium Tc 99m Methylenediphosphonate
  • UNII-X89XV46R07

Registry Numbers

CAS Registry Number

  • 121524-79-6

FDA UNII

  • X89XV46R07

System Generated Number

  • 0121524796

Structure Descriptors

InChI

InChI=1S/CH6O6P2.2H2O.Tc/c2-8(3,4)1-9(5,6)7;;;/h1H2,(H2,2,3,4)(H2,5,6,7);2*1H2;/q;;;+4/p-4/i;;;1+1

InChIKey

IUPNVOAUFBLQME-SGNQUONSSA-J

Smiles

[O-]P1(=O)CP(=O)([O-])[O-][99Tc+4]([OH2])([OH2])[O-]1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 75mg/kg (75mg/kg)   Drugs in Japan Vol. -, Pg. 802, 1995.
rat LD50 intravenous 67mg/kg (67mg/kg)   Drugs in Japan Vol. -, Pg. 802, 1995.