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Substance Name: Mirimostim [INN:JAN]
RN: 121547-04-4
UNII: GU09NM7537

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C1058-H1651-N277-O341-S14

Molecular Weight

  • 24166.1545
 
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Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)

Names and Synonyms

Name of Substance

  • Mirimostim
  • Mirimostim [INN:JAN]

Synonyms

  • Mirimostim
  • Mirimostime
  • Mirimostime [INN-French]
  • Mirimostimum
  • Mirimostimum [INN-Latin]
  • UNII-GU09NM7537

Systematic Names

  • 1-214-Colony-stimulating factor 1 (human clone p3ACSF-69 protein moiety reduced)
  • 1-214-Colony-stimulating factor 1 (human clone p3ACSF-69 protein moiety reduced), homodimer

Registry Numbers

CAS Registry Number

  • 121547-04-4

FDA UNII

  • GU09NM7537

System Generated Number

  • 0121547044

Structure Descriptors

Smiles

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]4CSSC[C@@H]5NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc6cnc[nH]6)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc7ccc(O)cc7)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc8ccccc8)NC(=O)[C@@H]9CSSC[C@H](NC(=O)[C@H](Cc%10ccc(O)cc%10)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%11cnc[nH]%11)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc%12cnc[nH]%12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc%13ccccc%13)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc%14ccccc%14)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N%15CCC[C@H]%15C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc%16ccccc%16)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc%17c[nH]c%18ccccc%17%18)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc%19ccccc%19)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]%20CCCN%20C(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc%21ccc(O)cc%21)NC(=O)[C@H](Cc%22ccccc%22)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC5=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%23ccccc%23)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N4)C(=O)N[C@@H](Cc%24ccc(O)cc%24)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc%25ccccc%25)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc%26ccccc%26)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N%27CCC[C@H]%27C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N9)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O)C(=O)N%28CCC[C@H]%28C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N%29CCC[C@H]%29C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N%30CCC[C@H]%30C(=O)N[C@@H](Cc%31cnc[nH]%31)C(=O)N[C@@H](CCC(=O)N)C(=O)N%32CCC[C@H]%32C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N%33CCC[C@H]%33C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N%34CCC[C@H]%34C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc%35c[nH]c%36ccccc%35%36)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N%37CCC[C@H]%37C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N%38CCC[C@H]%38C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc%39cnc[nH]%39)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N%40CCC[C@H]%40C(=O)NCC(=O)N[C@@H](CO)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
monkey LD50 intraperitoneal > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
monkey LD50 intravenous > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
mouse LD50 intravenous > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
mouse LD50 oral > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
mouse LD50 subcutaneous > 10000ku/kg (10000000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 2181, 1991.
rat LD50 intravenous > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
rat LD50 oral > 50000ku/kg (50000000iu/kg)   Yakkyoku. Pharmacy. Vol. 42, Pg. 1689, 1991.
rat LD50 subcutaneous > 10000ku/kg (10000000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 2181, 1991.