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Substance Name: Xylometazoline hydrochloride [USP]
RN: 1218-35-5
UNII: X5S84033NZ
InChIKey: YGWFCQYETHJKNX-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Pharmaceutic Aid (Tablet and Capsule Diluent)

Molecular Formula

  • C16-H24-N2.Cl-H

Molecular Weight

  • 280.841
 
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Names and Synonyms

Name of Substance

  • Xylometazoline hydrochloride [USP]

Synonyms

  • 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-, monohydrochloride
  • 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride
  • 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline monohydrochloride
  • EINECS 214-936-4
  • Neo-Synephrine II
  • Olynth
  • Otrivin
  • Otrivin Hydrochloride
  • Otrivine
  • Rhinactin
  • UNII-X5S84033NZ
  • Xylometazoline HCl
  • Xylometazoline hydrochloride

Systematic Names

  • 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-, hydrochloride (1:1)
  • 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-, monohydrochloride
  • 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-, monohydrochloride
  • Xylometazoline hydrochloride

Registry Numbers

CAS Registry Number

  • 1218-35-5

FDA UNII

  • X5S84033NZ

Other Registry Numbers

  • 28096-10-8
  • 8057-34-9

Related Registry Number

  • 526-36-3 (Parent)

System Generated Number

  • 0001218355

Molecular Formulas

Molecular Formula

  • C16-H24-N2.Cl-H

Molecular Formula Fragments

  • C16-H24-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H

InChIKey

YGWFCQYETHJKNX-UHFFFAOYSA-N

Smiles

c1(c(cc(C(C)(C)C)cc1C)C)CC1=NCC[NH+]1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 12500ug/kg (12.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
mouse LD50 oral 75mg/kg (75mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
mouse LD50 subcutaneous 53mg/kg (53mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
rat LD50 intraperitoneal 43mg/kg (43mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
rat LD50 oral 230mg/kg (230mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
rat LD50 subcutaneous 90mg/kg (90mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.