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Substance Name: Phentermine [USAN:INN:BAN]
RN: 122-09-8
UNII: C045TQL4WP
InChIKey: DHHVAGZRUROJKS-UHFFFAOYSA-N

Note

  • A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.

Molecular Formula

  • C10-H15-N

Molecular Weight

  • 149.2355
 

Classification Codes

Classification Codes

  • Adrenergic Agents
  • Anorexic
  • Anti-Obesity Agents
  • Appetite Depressants
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Stimulants
  • Human Data
  • Mutation Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympathomimetics

Superlist Classification Codes

  • DEA Schedule IV
  • Reportable Quantity (RQ) = 5000 lb

Names and Synonyms

Name of Substance

  • Phentermine
  • Phentermine [USAN:INN:BAN]

MeSH Heading

  • Phentermine

Synonyms

  • 1,1-Dimethyl-2-phenylethylamine
  • 2-Amino-2-methyl-1-phenylpropane
  • 2-Phenyl-tert-butylamine
  • 4-12-00-02820 (Beilstein Handbook Reference)
  • alpha,alpha-Dimethyl-beta-phenylethylamine
  • alpha,alpha-Dimethylbenzeneethanamine
  • alpha,alpha-Dimethylphenethylamine
  • alpha-Benzylisopropylamine
  • BRN 0970319
  • Duromine
  • EC 204-522-1
  • EINECS 204-522-1
  • Ethanamine, 1,1-dimethyl-2-phenyl-
  • Fastin
  • Fentermina
  • Fentermina [INN-Spanish]
  • HSDB 3158
  • Ionamin
  • Linyl
  • Lipopill
  • Lonamin
  • Mirapront
  • Normephentermine
  • Obermine
  • Omnibex
  • Phentermine
  • Phenterminum
  • Phenterminum [INN-Latin]
  • Phentrol
  • Phentrol 2
  • Phentrol 3
  • Phentrol 4
  • Phenyl-tert-butylamine
  • Phenyl-tertiary-butylamine
  • RCRA waste number P046
  • UNII-C045TQL4WP
  • Wilpo

Systematic Names

  • Benzeneethanamine, alpha,alpha-dimethyl-
  • Phenethylamine, alpha,alpha-dimethyl-
  • Phentermine

Superlist Names

  • alpha,alpha-Dimethylphenethylamine
  • Benzeneethanamine, alpha,alpha-dimethyl-
  • DEA No. 1640
  • Phentermine
  • RCRA waste no. P046

Registry Numbers

CAS Registry Number

  • 122-09-8

FDA UNII

  • C045TQL4WP

Other Registry Numbers

  • 12674-13-4
  • 9008-94-0

Related Registry Number

  • 1197-21-3 (hydrochloride)

System Generated Number

  • 0000122098

Structure Descriptors

InChI

1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3

InChIKey

DHHVAGZRUROJKS-UHFFFAOYSA-N

Smiles

c1(CC(C)(C)N)ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1429ug/kg (1.429mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Therapie. Vol. 34, Pg. 205, 1979.
mouse LD50 intraperitoneal 71mg/kg (71mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 14, Pg. 677, 1976.
mouse LD50 intravenous 14mg/kg (14mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03232,
mouse LD50 oral 105mg/kg (105mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 62, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 205 deg C   EXP
log P (octanol-water) 1.9 (none)   EXP
Water Solubility 1.86E+04 mg/L 25 EST
Vapor Pressure 0.096 mm Hg 25 EST
Henry's Law Constant 1.43E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.73E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.