|
|
Substance Name: Fenitrothion [BAN]
RN: 122-14-5
UNII: W8M4X3Y7ZY
InChIKey: ZNOLGFHPUIJIMJ-UHFFFAOYSA-N
Note
- An organothiophosphate cholinesterase inhibitor that is used as an insecticide.
Molecular Formula
- C9-H12-N-O5-P-S
Molecular Weight
- 277.2358
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Acaricide
- Agricultural Chemical
- Cholinergic Agents
- Cholinesterase Inhibitors
- Enzyme Inhibitors
- Human Data
- Insecticide
- Insecticides
- Mutation Data
- Neurotransmitter Agents
- Pesticides
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Fenitrothion
- Fenitrothion [BAN]
- Fenitrothion [BSI:ISO]
MeSH Heading
- Fenitrothion
Synonyms
- 3-Methyl-4-nitrophenyl dimethyl phosphorothioate
- 8057HC
- AC-47300
- Accothion
- Agria 1050
- Agriya 1050
- Agrothion
- AI3-25715
- Akotion
- American cyanamid CL-47,300
- Arbogal
- BAY 41831
- Bayer 41831
- Bayer S 5660
- BRN 1887367
- C-9146
- Caswell No. 373
- CCRIS 1559
- Cekutrothion
- CL 47300
- CP 47114
- Cyfen
- Cytel
- Dimethyl (3-methyl-4-nitrophenyl) thiophosphate
- Dimethyl 3-methyl-4-nitrophenyl phosphorothionate
- Dimethyl 4-nitro-m-tolyl phosphorothionate
- Dimethyl-(3-methyl-4-nitrophenyl)thiophosphate
- EI 47300
- EINECS 204-524-2
- ENT 25,715
- EPA Pesticide Chemical Code 105901
- Falithion
- Fenition
- Fenitox
- Fenitrothion
- Fenitrotion (Hungarian)
- Fentrothione
- Folithion
- Folithion EC 50
- HSDB 1590
- Insectigas F
- Kotion
- m-Cresol, 4-nitro-, O-ester with O,O-dimethyl phosphorothioate
- Macbar
- MEP (pesticide)
- Metathion
- Metathion E 50
- Metathione
- Metathionine
- Metathionine E50
- Metation
- Metation E50
- Methylnitrophos
- Mglawik F
- Monsanto CP 47114
- Nitrophos
- Novathion
- Nuvanol
- O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
- O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate
- O,O-Dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate
- O,O-Dimethyl O-(4-nitro-3-methylphenyl) thiophosphate
- O,O-Dimethyl O-(4-nitro-3-methylphenyl)thiophosphate
- O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
- O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat
- O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat [German]
- O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat
- O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat [Dutch]
- O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat
- O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat [German]
- O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato
- O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato [Italian]
- O,O-Dimetil-O-(3-metil-4-nitrofenil) fosforotioato (Portugese)
- Oleosumifene
- OMS 43
- Ovadofos
- Owadofos
- Owadophos
- Pennwalt C-4852
- Phenitrothion
- Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
- Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester
- S 112A
- S-1102A
- Sumifene
- Sumithion
- Sumitomo S-1102A
- Super Sumithion
- Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle)
- Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle) [French]
- Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy
- Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy [Polish]
- UNII-W8M4X3Y7ZY
- Verthion
Systematic Names
- Fenitrothion
- O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
- Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
- Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester
Superlist Name
- Fenitrothion
Registry Numbers
CAS Registry Number
- 122-14-5
FDA UNII
- W8M4X3Y7ZY
Other Registry Numbers
- 12764-87-3
- 54182-70-6
- 94650-98-3
System Generated Number
- 0000122145
Structure Descriptors
InChI
InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3InChIKey
ZNOLGFHPUIJIMJ-UHFFFAOYSA-NSmiles
COP(=S)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 11mg/kg (11mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
cat | LD50 | oral | 142mg/kg (142mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
cattle | LD50 | unreported | 217mg/kg (217mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Indian Journal of Animal Sciences. Vol. 49, Pg. 314, 1979. |
chicken | LD50 | oral | 280mg/kg (280mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967. |
duck | LD50 | oral | 1190mg/kg (1190mg/kg) | Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979. | |
duck | LD50 | skin | 504mg/kg (504mg/kg) | Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979. | |
guinea pig | LD50 | intravenous | 112mg/kg (112mg/kg) | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. | |
guinea pig | LD50 | intravenous | 112mg/kg (112mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. |
guinea pig | LD50 | oral | 500mg/kg (500mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
mammal (species unspecified) | LD50 | unreported | 142mg/kg (142mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 330, 1971. | |
man | LDLo | oral | 429uL/kg (0.429mL/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: COMA | Human Toxicology. Vol. 6, Pg. 403, 1987. |
mouse | LD50 | intracrebral | 1gm/kg (1000mg/kg) | Pesticide Biochemistry and Physiology. Vol. 8, Pg. 302, 1978. | |
mouse | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
mouse | LD50 | oral | 229mg/kg (229mg/kg) | Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 635, 1978. | |
mouse | LD50 | skin | 2500mg/kg (2500mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
mouse | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
mouse | LD50 | unreported | 470mg/kg (470mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(5), Pg. 38, 1963. | |
quail | LD50 | oral | 56200ug/kg (56.2mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
rabbit | LD50 | skin | 1250mg/kg (1250mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(10), Pg. 12, 1966. | |
rat | LC50 | inhalation | 378mg/m3/4H (378mg/m3) | BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Egeszsegtudomany. Vol. 24, Pg. 173, 1980. |
rat | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982. |
rat | LD50 | intratracheal | 950mg/kg (950mg/kg) | BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982. |
rat | LD50 | intravenous | 33mg/kg (33mg/kg) | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. | |
rat | LD50 | intravenous | 33mg/kg (33mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. |
rat | LD50 | oral | 250mg/kg (250mg/kg) | Journal of Economic Entomology. Vol. 61, Pg. 743, 1968. | |
rat | LD50 | skin | 1002mg/kg (1002mg/kg) | Arquivos do Instituto Biologico, Sao Paulo. Vol. 37, Pg. 219, 1970. | |
rat | LD50 | subcutaneous | 1300mg/kg (1300mg/kg) | Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 13, Pg. 401, 1988. | |
rat | LD50 | unreported | 290mg/kg (290mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 74, Pg. 41P, 1978. | |
women | TDLo | oral | 800mg/kg (800mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archives of Toxicology. Vol. 56, Pg. 136, 1984. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 3.4 | deg C | EXP | |
log P (octanol-water) | 3.3 | (none) | EXP | |
Water Solubility | 38 | mg/L | 25 | EXP |
Vapor Pressure | 5.40E-05 | mm Hg | 20 | EXP |
Henry's Law Constant | 9.30E-07 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 6.21E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.