Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: Fenitrothion [BAN]
RN: 122-14-5
UNII: W8M4X3Y7ZY
InChIKey: ZNOLGFHPUIJIMJ-UHFFFAOYSA-N

Note

  • An organothiophosphate cholinesterase inhibitor that is used as an insecticide.

Molecular Formula

  • C9-H12-N-O5-P-S

Molecular Weight

  • 277.2358
 

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Human Data
  • Insecticide
  • Insecticides
  • Mutation Data
  • Neurotransmitter Agents
  • Pesticides
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Fenitrothion
  • Fenitrothion [BAN]
  • Fenitrothion [BSI:ISO]

MeSH Heading

  • Fenitrothion

Synonyms

  • 3-Methyl-4-nitrophenyl dimethyl phosphorothioate
  • 8057HC
  • AC-47300
  • Accothion
  • Agria 1050
  • Agriya 1050
  • Agrothion
  • AI3-25715
  • Akotion
  • American cyanamid CL-47,300
  • Arbogal
  • BAY 41831
  • Bayer 41831
  • Bayer S 5660
  • BRN 1887367
  • C-9146
  • Caswell No. 373
  • CCRIS 1559
  • Cekutrothion
  • CL 47300
  • CP 47114
  • Cyfen
  • Cytel
  • Dimethyl (3-methyl-4-nitrophenyl) thiophosphate
  • Dimethyl 3-methyl-4-nitrophenyl phosphorothionate
  • Dimethyl 4-nitro-m-tolyl phosphorothionate
  • Dimethyl-(3-methyl-4-nitrophenyl)thiophosphate
  • EI 47300
  • EINECS 204-524-2
  • ENT 25,715
  • EPA Pesticide Chemical Code 105901
  • Falithion
  • Fenition
  • Fenitox
  • Fenitrothion
  • Fenitrotion (Hungarian)
  • Fentrothione
  • Folithion
  • Folithion EC 50
  • HSDB 1590
  • Insectigas F
  • Kotion
  • m-Cresol, 4-nitro-, O-ester with O,O-dimethyl phosphorothioate
  • Macbar
  • MEP (pesticide)
  • Metathion
  • Metathion E 50
  • Metathione
  • Metathionine
  • Metathionine E50
  • Metation
  • Metation E50
  • Methylnitrophos
  • Mglawik F
  • Monsanto CP 47114
  • Nitrophos
  • Novathion
  • Nuvanol
  • O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
  • O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate
  • O,O-Dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate
  • O,O-Dimethyl O-(4-nitro-3-methylphenyl) thiophosphate
  • O,O-Dimethyl O-(4-nitro-3-methylphenyl)thiophosphate
  • O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
  • O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat
  • O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat [German]
  • O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat
  • O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat [Dutch]
  • O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat
  • O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat [German]
  • O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato
  • O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato [Italian]
  • O,O-Dimetil-O-(3-metil-4-nitrofenil) fosforotioato (Portugese)
  • Oleosumifene
  • OMS 43
  • Ovadofos
  • Owadofos
  • Owadophos
  • Pennwalt C-4852
  • Phenitrothion
  • Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
  • Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester
  • S 112A
  • S-1102A
  • Sumifene
  • Sumithion
  • Sumitomo S-1102A
  • Super Sumithion
  • Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle)
  • Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle) [French]
  • Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy
  • Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy [Polish]
  • UNII-W8M4X3Y7ZY
  • Verthion

Systematic Names

  • Fenitrothion
  • O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
  • Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
  • Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester

Superlist Name

  • Fenitrothion

Registry Numbers

CAS Registry Number

  • 122-14-5

FDA UNII

  • W8M4X3Y7ZY

Other Registry Numbers

  • 12764-87-3
  • 54182-70-6
  • 94650-98-3

System Generated Number

  • 0000122145

Structure Descriptors

InChI

InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3

InChIKey

ZNOLGFHPUIJIMJ-UHFFFAOYSA-N

Smiles

COP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 11mg/kg (11mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LD50 oral 142mg/kg (142mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
cattle LD50 unreported 217mg/kg (217mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Indian Journal of Animal Sciences. Vol. 49, Pg. 314, 1979.
chicken LD50 oral 280mg/kg (280mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
duck LD50 oral 1190mg/kg (1190mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
duck LD50 skin 504mg/kg (504mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
guinea pig LD50 intravenous 112mg/kg (112mg/kg)   Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
guinea pig LD50 intravenous 112mg/kg (112mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
guinea pig LD50 oral 500mg/kg (500mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
mammal (species unspecified) LD50 unreported 142mg/kg (142mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 330, 1971.
man LDLo oral 429uL/kg (0.429mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: COMA		 Human Toxicology. Vol. 6, Pg. 403, 1987.
mouse LD50 intracrebral 1gm/kg (1000mg/kg)   Pesticide Biochemistry and Physiology. Vol. 8, Pg. 302, 1978.
mouse LD50 intraperitoneal 280mg/kg (280mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
mouse LD50 oral 229mg/kg (229mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 635, 1978.
mouse LD50 skin 2500mg/kg (2500mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
mouse LD50 unreported 470mg/kg (470mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(5), Pg. 38, 1963.
quail LD50 oral 56200ug/kg (56.2mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit LD50 skin 1250mg/kg (1250mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(10), Pg. 12, 1966.
rat LC50 inhalation 378mg/m3/4H (378mg/m3) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Egeszsegtudomany. Vol. 24, Pg. 173, 1980.
rat LD50 intraperitoneal 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC		 Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982.
rat LD50 intratracheal 950mg/kg (950mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC		 Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982.
rat LD50 intravenous 33mg/kg (33mg/kg)   Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
rat LD50 intravenous 33mg/kg (33mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
rat LD50 oral 250mg/kg (250mg/kg)   Journal of Economic Entomology. Vol. 61, Pg. 743, 1968.
rat LD50 skin 1002mg/kg (1002mg/kg)   Arquivos do Instituto Biologico, Sao Paulo. Vol. 37, Pg. 219, 1970.
rat LD50 subcutaneous 1300mg/kg (1300mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 13, Pg. 401, 1988.
rat LD50 unreported 290mg/kg (290mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 74, Pg. 41P, 1978.
women TDLo oral 800mg/kg (800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Archives of Toxicology. Vol. 56, Pg. 136, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 3.4 deg C   EXP
log P (octanol-water) 3.3 (none)   EXP
Water Solubility 38 mg/L 25 EXP
Vapor Pressure 5.40E-05 mm Hg 20 EXP
Henry's Law Constant 9.30E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 6.21E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.