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Substance Name: Fenitrothion [BAN]
RN: 122-14-5
UNII: W8M4X3Y7ZY
InChIKey: ZNOLGFHPUIJIMJ-UHFFFAOYSA-N

Note

  • An organothiophosphate cholinesterase inhibitor that is used as an insecticide.

Molecular Formula

  • C9-H12-N-O5-P-S

Molecular Weight

  • 277.2358
 

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Human Data
  • Insecticide
  • Insecticides
  • Mutation Data
  • Neurotransmitter Agents
  • Pesticides
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Fenitrothion
  • Fenitrothion [BAN]
  • Fenitrothion [BSI:ISO]

MeSH Heading

  • Fenitrothion

Synonyms

  • 3-Methyl-4-nitrophenyl dimethyl phosphorothioate
  • 8057HC
  • AC-47300
  • Accothion
  • Agria 1050
  • Agriya 1050
  • Agrothion
  • AI3-25715
  • Akotion
  • American cyanamid CL-47,300
  • Arbogal
  • BAY 41831
  • Bayer 41831
  • Bayer S 5660
  • BRN 1887367
  • C-9146
  • Caswell No. 373
  • CCRIS 1559
  • Cekutrothion
  • CL 47300
  • CP 47114
  • Cyfen
  • Cytel
  • Dimethyl (3-methyl-4-nitrophenyl) thiophosphate
  • Dimethyl 3-methyl-4-nitrophenyl phosphorothionate
  • Dimethyl 4-nitro-m-tolyl phosphorothionate
  • Dimethyl-(3-methyl-4-nitrophenyl)thiophosphate
  • EI 47300
  • EINECS 204-524-2
  • ENT 25,715
  • EPA Pesticide Chemical Code 105901
  • Falithion
  • Fenition
  • Fenitox
  • Fenitrothion
  • Fenitrotion (Hungarian)
  • Fentrothione
  • Folithion
  • Folithion EC 50
  • HSDB 1590
  • Insectigas F
  • Kotion
  • m-Cresol, 4-nitro-, O-ester with O,O-dimethyl phosphorothioate
  • Macbar
  • MEP (pesticide)
  • Metathion
  • Metathion E 50
  • Metathione
  • Metathionine
  • Metathionine E50
  • Metation
  • Metation E50
  • Methylnitrophos
  • Mglawik F
  • Monsanto CP 47114
  • Nitrophos
  • Novathion
  • Nuvanol
  • O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
  • O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate
  • O,O-Dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate
  • O,O-Dimethyl O-(4-nitro-3-methylphenyl) thiophosphate
  • O,O-Dimethyl O-(4-nitro-3-methylphenyl)thiophosphate
  • O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
  • O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat
  • O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat [German]
  • O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat
  • O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat [Dutch]
  • O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat
  • O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat [German]
  • O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato
  • O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato [Italian]
  • O,O-Dimetil-O-(3-metil-4-nitrofenil) fosforotioato (Portugese)
  • Oleosumifene
  • OMS 43
  • Ovadofos
  • Owadofos
  • Owadophos
  • Pennwalt C-4852
  • Phenitrothion
  • Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
  • Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester
  • S 112A
  • S-1102A
  • Sumifene
  • Sumithion
  • Sumitomo S-1102A
  • Super Sumithion
  • Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle)
  • Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle) [French]
  • Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy
  • Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy [Polish]
  • UNII-W8M4X3Y7ZY
  • Verthion

Systematic Names

  • Fenitrothion
  • O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
  • Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
  • Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester

Superlist Name

  • Fenitrothion

Registry Numbers

CAS Registry Number

  • 122-14-5

FDA UNII

  • W8M4X3Y7ZY

Other Registry Numbers

  • 12764-87-3
  • 54182-70-6
  • 94650-98-3

System Generated Number

  • 0000122145

Structure Descriptors

InChI

InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3

InChIKey

ZNOLGFHPUIJIMJ-UHFFFAOYSA-N

Smiles

COP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 11mg/kg (11mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LD50 oral 142mg/kg (142mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
cattle LD50 unreported 217mg/kg (217mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Indian Journal of Animal Sciences. Vol. 49, Pg. 314, 1979.
chicken LD50 oral 280mg/kg (280mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
duck LD50 oral 1190mg/kg (1190mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
duck LD50 skin 504mg/kg (504mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
guinea pig LD50 intravenous 112mg/kg (112mg/kg)   Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
guinea pig LD50 intravenous 112mg/kg (112mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
guinea pig LD50 oral 500mg/kg (500mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
mammal (species unspecified) LD50 unreported 142mg/kg (142mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 330, 1971.
man LDLo oral 429uL/kg (0.429mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: COMA		 Human Toxicology. Vol. 6, Pg. 403, 1987.
mouse LD50 intracrebral 1gm/kg (1000mg/kg)   Pesticide Biochemistry and Physiology. Vol. 8, Pg. 302, 1978.
mouse LD50 intraperitoneal 280mg/kg (280mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
mouse LD50 oral 229mg/kg (229mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 635, 1978.
mouse LD50 skin 2500mg/kg (2500mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
mouse LD50 unreported 470mg/kg (470mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(5), Pg. 38, 1963.
quail LD50 oral 56200ug/kg (56.2mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit LD50 skin 1250mg/kg (1250mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(10), Pg. 12, 1966.
rat LC50 inhalation 378mg/m3/4H (378mg/m3) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Egeszsegtudomany. Vol. 24, Pg. 173, 1980.
rat LD50 intraperitoneal 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC		 Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982.
rat LD50 intratracheal 950mg/kg (950mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC		 Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982.
rat LD50 intravenous 33mg/kg (33mg/kg)   Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
rat LD50 intravenous 33mg/kg (33mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963.
rat LD50 oral 250mg/kg (250mg/kg)   Journal of Economic Entomology. Vol. 61, Pg. 743, 1968.
rat LD50 skin 1002mg/kg (1002mg/kg)   Arquivos do Instituto Biologico, Sao Paulo. Vol. 37, Pg. 219, 1970.
rat LD50 subcutaneous 1300mg/kg (1300mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 13, Pg. 401, 1988.
rat LD50 unreported 290mg/kg (290mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 74, Pg. 41P, 1978.
women TDLo oral 800mg/kg (800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Archives of Toxicology. Vol. 56, Pg. 136, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 3.4 deg C   EXP
log P (octanol-water) 3.3 (none)   EXP
Water Solubility 38 mg/L 25 EXP
Vapor Pressure 5.40E-05 mm Hg 20 EXP
Henry's Law Constant 9.30E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 6.21E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.