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Substance Name: Sulfamonomethoxine [USAN:INN:BAN:JAN]
RN: 1220-83-3
UNII: U700P169W2
InChIKey: WMPXPUYPYQKQCX-UHFFFAOYSA-N

Note

  • Long acting sulfonamide antibacterial agent.

Molecular Formula

  • C11-H12-N4-O3-S

Molecular Weight

  • 280.3068
 

Classification Codes

  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Sulfamonomethoxine
  • Sulfamonomethoxine [USAN:INN:BAN:JAN]

MeSH Heading

  • Sulfamonomethoxine

Synonyms

  • 5-25-12-00493 (Beilstein Handbook Reference)
  • BRN 0621128
  • Daimeton
  • DJ-1550
  • DS-36
  • ICI 32525
  • N(sup 1)-(6-Methoxy-4-pyrimidinyl)sulfanilamide
  • N1-(6-Methoxy-4-pyrimidinyl)sulfanilamide
  • Ro 4-3476
  • Sulfamonomethoxin
  • Sulfamonomethoxine
  • Sulfamonomethoxinum
  • Sulfamonomethoxinum [INN-Latin]
  • Sulfamonometoxina
  • Sulfamonometoxina [INN-Spanish]
  • UNII-U700P169W2

Systematic Names

  • Benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)-
  • Sulfanilamide, N(sup 1)-(6-methoxy-4-pyrimidinyl)-

Registry Numbers

CAS Registry Number

  • 1220-83-3

FDA UNII

  • U700P169W2

System Generated Number

  • 0001220833

Structure Descriptors

InChI

1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)

InChIKey

WMPXPUYPYQKQCX-UHFFFAOYSA-N

Smiles

COc1cc(ncn1)NS(=O)(=O)c2ccc(cc2)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral > 10gm/kg (10000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
dog LD50 oral > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
mouse LD50 intraperitoneal 865mg/kg (865mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse LD50 intravenous 1010mg/kg (1010mg/kg)   Drugs in Japan Vol. 6, Pg. 391, 1982.
mouse LD50 oral 4680mg/kg (4680mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 58, Pg. 59, 1962.
mouse LD50 subcutaneous > 7gm/kg (7000mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rabbit LD50 oral > 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rat LD50 intraperitoneal 2440mg/kg (2440mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: IRRITABILITY
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rat LD50 oral > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rat LD50 subcutaneous > 7gm/kg (7000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.7 (none)   EXP
Water Solubility 4030 mg/L 25 EST
Vapor Pressure 8.35E-09 mm Hg 25 EST
Henry's Law Constant 2.41E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.93E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.