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Substance Name: Clofexamide [INN:DCF]
RN: 1223-36-5
UNII: 071P4J77HF
InChIKey: UORGKWWJEQDTGX-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C14-H21-Cl-N2-O2

Molecular Weight

  • 284.785
 
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Names and Synonyms

Name of Substance

  • Clofexamide
  • Clofexamide [INN:DCF]

Synonyms

  • 2-(p-Chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide
  • Amichlophene
  • ANP 246
  • BRN 1986755
  • Chlofexamide
  • Clofexamida
  • Clofexamida [INN-Spanish]
  • Clofexamide
  • Clofexamidum
  • Clofexamidum [INN-Latin]
  • EINECS 214-951-6
  • IEM 455
  • NP 246
  • UNII-071P4J77HF

Systematic Names

  • 2-(p-Chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide
  • Acetamide, 2-(4-chlorophenoxy)-N-(2-(diethylamino)ethyl)- (9CI)
  • Acetamide, 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl)-
  • Clofexamide
  • N-(2-Diethylaminoethyl)-4-chlorophenoxyacetamide

Registry Numbers

CAS Registry Number

  • 1223-36-5

FDA UNII

  • 071P4J77HF

Other Registry Number

  • 55963-10-5

Related Registry Number

  • 3482-74-4 (mono-hydrochloride)

System Generated Number

  • 0001223365

Structure Descriptors

InChI

1S/C14H21ClN2O2/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13/h5-8H,3-4,9-11H2,1-2H3,(H,16,18)

InChIKey

UORGKWWJEQDTGX-UHFFFAOYSA-N

Smiles

c1cc(ccc1Cl)OCC(NCCN(CC)CC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 290mg/kg (290mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Farmakologiya i Toksikologiya Vol. 38, Pg. 154, 1975.
mouse LD50 intravenous 145mg/kg (145mg/kg)   French Medicament Patent Document. Vol. #2702M,
mouse LD50 oral 1200ug/kg (1.2mg/kg)   Chimica Therapeutica. Vol. 1, Pg. 444, 1966.
rabbit LD50 intravenous 167mg/kg (167mg/kg)   French Medicament Patent Document. Vol. #2702M,
rat LD50 oral 1040mg/kg (1040mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 935, 1979.