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Substance Name: Larotrectinib [USAN:INN]
RN: 1223403-58-4
UNII: PF9462I9HX
InChIKey: NYNZQNWKBKUAII-KBXCAEBGSA-N
Note
- A TRK kinase inhibitor.
NCI: Trk inhibitor LOXO-101 An orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, LOXO-101 binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. (NCI Thesaurus)
Molecular Formula
- C21-H22-F2-N6-O2
Molecular Weight
- 428.4408
Classification Code
- Treatment of TRK Positive Tumors
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Names and Synonyms
Name of Substance
- Larotrectinib [USAN:INN]
Synonyms
- 1-Pyrrolidinecarboxamide, N-(5-((2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxy-, (3S)-
- ARRY 470
- Larotrectinib
- LOXO 101
- LOXO-101
- UNII-PF9462I9HX
Systematic Name
- (3S)-N-(5-((2R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine- 1-carboxamide
Registry Numbers
CAS Registry Number
- 1223403-58-4
FDA UNII
- PF9462I9HX
System Generated Number
- 1223403584