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Substance Name: Gold sodium thiomalate [USAN:USP]
RN: 12244-57-4
UNII: E4768ZY6GM
InChIKey: VXIHRIQNJCRFQX-UHFFFAOYSA-K

Note

  • A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.

Molecular Formula

  • C4-H6-O4-S.Au.x-Na

Molecular Weight

  • 390.08
 

Classification Codes

  • Antirheumatic
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Gold sodium thiomalate
  • Gold sodium thiomalate [USAN:USP]
  • Sodium aurothiomalate [INN]

MeSH Heading

  • Gold sodium thiomalate

Synonyms

  • Aurothiomala-Natrium
  • Aurothiomalate de sodium
  • Aurothiomalate de sodium [INN-French]
  • Aurothiomalate sodium
  • Aurothiomalato sodico
  • Aurotiomalato sodico
  • Aurotiomalato sodico [INN-Spanish]
  • Butanedioic acid, mercapto-, monogold(1+) sodium salt
  • Chrysothios
  • Dinatrium 2-(aurothio)succinat
  • EINECS 235-479-7
  • Gold sodium thiomalate
  • HSDB 7173
  • Kidon
  • Miochrysin
  • Myochrysine
  • Myocrisin
  • Myocrisine
  • Natrii aurothiomalas
  • Natrii aurothiomalas [INN-Latin]
  • Sodium aurothiomalate
  • Succinic acid, mercapto-, gold sodium salt
  • Taure(o)don
  • Tauredon
  • UNII-E4768ZY6GM

Systematic Names

  • Butanedioic acid, mercapto-, monogold(1+) sodium salt
  • Sodium aurothiomalate

Registry Numbers

CAS Registry Number

  • 12244-57-4

FDA UNII

  • E4768ZY6GM

Other Registry Numbers

  • 12544-40-0
  • 14481-64-2
  • 16905-00-3
  • 18911-13-2
  • 23164-93-4
  • 3504-43-6
  • 3829-87-6
  • 3845-05-4
  • 554-42-7
  • 62695-99-2
  • 62696-00-8

Related Registry Number

  • 39377-38-3 (di-hydrochloride salt, mono-hydrate)

System Generated Number

  • 0012244574

Molecular Formulas

Molecular Formula

  • C4-H6-O4-S.Au.x-Na

Molecular Formula Fragments

  • Au
  • C4-H6-O4-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C4H6O4S.Au.2Na/c5-3(6)1-2(9)4(7)8;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;/q;3*+1/p-3

InChIKey

VXIHRIQNJCRFQX-UHFFFAOYSA-K

Smiles

C([C@@H](C(=O)[O-])S[Au])C(=O)[O-].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo unreported 11900ug/kg/18 (11.9mg/kg)   Journal of Rheumatology. Vol. 13, Pg. 224, 1986.
human TDLo unreported 9750ug/kg/23W (9.75mg/kg) BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)

BLOOD: APLASTIC ANEMIA

BLOOD: OTHER CHANGES
British Medical Journal. Vol. 1, Pg. 1266, 1976.
man TDLo intramuscular 5mg/kg/13W (5mg/kg) MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES

BLOOD: HEMORRHAGE

BLOOD: THROMBOCYTOPENIA
JAMA, Journal of the American Medical Association. Vol. 133, Pg. 754, 1947.
man TDLo oral 5500ug/kg (5.5mg/kg) KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED

BLOOD: THROMBOCYTOPENIA

PERIPHERAL NERVE AND SENSATION: RECORDING FROM PERIPHERAL MOTOR NERVE
Arthritis and Rheumatism. Vol. 19, Pg. 936, 1976.
man TDLo parenteral 7857ug/kg/11W (7.857mg/kg)   British Medical Journal. Vol. 286, Pg. 1547, 1983.
man TDLo parenteral 7857ug/kg/11W (7.857mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 286, Pg. 1547, 1983.
man TDLo parenteral 12500ug/kg/7W (12.5mg/kg) PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH

PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

BRAIN AND COVERINGS: ENCEPHALITIS
Journal of Rheumatology. Vol. 11, Pg. 233, 1984.
man TDLo unreported 7857ug/kg/11W (7.857mg/kg)   British Journal of Rheumatology. Vol. 24, Pg. 367, 1985.
man TDLo unreported 12mg/kg (12mg/kg) BLOOD: THROMBOCYTOPENIA Journal of Rheumatology. Vol. 13, Pg. 225, 1986.
mouse LD50 intramuscular 800mg/kg (800mg/kg)   Veterinary Pathology. Vol. 15(Suppl,
mouse LD50 intravenous 855mg/kg (855mg/kg)   Drugs in Japan Vol. 6, Pg. 208, 1982.
mouse LD50 subcutaneous 930mg/kg (930mg/kg)   Drugs in Japan Vol. 6, Pg. 208, 1982.
rat LD50 intravenous 440mg/kg (440mg/kg)   Drugs in Japan Vol. 6, Pg. 208, 1982.
rat LD50 subcutaneous 303mg/kg (303mg/kg)   Drugs in Japan Vol. 6, Pg. 208, 1982.
rat LDLo intramuscular 185mg/kg (185mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 49, Pg. 121, 1942.
women LDLo intramuscular 600ug/kg/1W-I (0.6mg/kg) LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

LIVER: "JAUNDICE, CHOLESTATIC"
Journal of the Royal Society of Medicine. Vol. 77, Pg. 960, 1984.
women TDLo intramuscular 182ug/kg (0.182mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 2, Pg. 1294, 1976.
women TDLo intramuscular 20mg/kg/1Y (20mg/kg) BEHAVIORAL: AGGRESSION

KIDNEY, URETER, AND BLADDER: PROTEINURIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives of Pathology. Vol. 96, Pg. 133, 1973.
women TDLo intravenous 2700ug/kg/4W- (2.7mg/kg) BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)" Journal of Rheumatology. Vol. 11, Pg. 235, 1984.
women TDLo oral 19mg/kg/26W-I (19mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: COUGH
Clinical and Experimental Rheumatology. Vol. 7, Pg. 89, 1989.
women TDLo oral 24mg/kg/24W-I (24mg/kg)   Clinical and Experimental Rheumatology. Vol. 3, Pg. 181, 1985.
women TDLo oral 24mg/kg/24W-I (24mg/kg) LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Clinical and Experimental Rheumatology. Vol. 3, Pg. 181, 1985.
women TDLo parenteral 3366ug/kg/2W (3.366mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Neurology. Vol. 20, Pg. 455, 1970.
women TDLo unreported 1600ug/kg/3W- (1.6mg/kg) BLOOD: AGRANULOCYTOSIS

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Australian and New Zealand Journal of Medicine. Vol. 16, Pg. 72, 1986.
women TDLo unreported 2200ug/kg/7W- (2.2mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
Archives of Pathology. Vol. 99, Pg. 36, 1975.
women TDLo unreported 7mg/kg/7W-I (7mg/kg) BLOOD: THROMBOCYTOPENIA Journal of Rheumatology. Vol. 12, Pg. 180, 1985.
women TDLo unreported 13mg/kg/22W-I (13mg/kg) KIDNEY, URETER, AND BLADDER: PROTEINURIS Archives of Pathology and Laboratory Medicine. Vol. 101, Pg. 635, 1977.