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Substance Name: Protriptyline hydrochloride [USAN:USP]
RN: 1225-55-4
UNII: 44665V00O8
InChIKey: OGQDIIKRQRZXJH-UHFFFAOYSA-N

Note

  • Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.

Molecular Formula

  • C19-H21-N.Cl-H

Molecular Weight

  • 299.8428
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Protriptyline hydrochloride [USAN:USP]

Synonyms

  • 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene hydrochloride
  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, hydrochloride
  • Concordin
  • EINECS 214-956-3
  • Maximed
  • MK-240
  • MK-240 (VAN)
  • N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine hydrochloride
  • Normethyl EX4442
  • NSC 169912
  • Protriptyline HCl
  • Protriptyline hydrochloride
  • Triptil (VAN)
  • Triptil hydrochloride
  • Triptyl
  • UNII-44665V00O8
  • Vivactil

Systematic Names

  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, hydrochloride
  • 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, hydrochloride (8CI)
  • Protriptyline hydrochloride

Registry Numbers

CAS Registry Number

  • 1225-55-4

FDA UNII

  • 44665V00O8

Related Registry Number

  • 438-60-8 (Parent)

System Generated Number

  • 0001225554

Molecular Formulas

Molecular Formula

  • C19-H21-N.Cl-H

Molecular Formula Fragments

  • C19-H21-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

InChIKey

OGQDIIKRQRZXJH-UHFFFAOYSA-N

Smiles

CNCCCC1c2ccccc2C=Cc3c1cccc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 400mg/kg (400mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
guinea pig LD50 intraperitoneal 21mg/kg (21mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
guinea pig LD50 oral 180mg/kg (180mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 12, Pg. 39, 1974.
mouse LD50 intravenous 49mg/kg (49mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 24, Pg. 121, 1966.
mouse LD50 oral 211mg/kg (211mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
mouse LD50 subcutaneous 192mg/kg (192mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
rabbit LD50 intravenous 8200ug/kg (8.2mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
rabbit LD50 oral 310mg/kg (310mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
rat LD50 intraperitoneal 44mg/kg (44mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
rat LD50 oral 299mg/kg (299mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.