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Substance Name: Isothipendyl hydrochloride [JAN]
RN: 1225-60-1
UNII: 953AP1LBV8
InChIKey: RQHCFTORMXCNGP-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H19-N3-S.Cl-H

Molecular Weight

  • 321.874
 
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Names and Synonyms

Name of Substance

  • Isothipendyl hydrochloride [JAN]

Synonyms

  • 10-(2-Dimethylamino-2-methylethyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
  • 10-(2-Dimethylaminopropyl)-(1)-4-azaphenthiazin hydrochlorid
  • 10-(2-Dimethylaminopropyl)-(1)-4-azaphenthiazin hydrochlorid [German]
  • 10-(2-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride
  • 10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
  • 10-(2-Dimethylaminopropyl)-9-thia-1,10-diazaanthracene hydrochloride
  • 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride
  • Adantol
  • Adanton hydrochloride
  • Andantol
  • Dimethylamino-isopropyl-thiophenyl-pyridylamin hydrochlorid
  • Dimethylamino-isopropyl-thiophenyl-pyridylamin hydrochlorid [German]
  • EINECS 214-957-9
  • Isothipendyl HCl
  • Isothipendyl hydrochloride
  • Isothipendyl monohydrochloride
  • N-Dimethylaminoisopropylthiophenylpyridylamine hydrochloride
  • Nilergex hydrochloride
  • NSC 169186
  • Theruhistin
  • Theruhistin hydrochloride
  • Udantol hydrochloride
  • UNII-953AP1LBV8

Systematic Names

  • 10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
  • 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride (8CI)
  • 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-dimethylamino-2-methylethyl)-, hydrochloride
  • 10H-Pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, N,N,2-trimethyl-, monohydrochloride (9CI)
  • Isothipendyl hydrochloride

Registry Numbers

CAS Registry Number

  • 1225-60-1

FDA UNII

  • 953AP1LBV8

System Generated Number

  • 0001225601

Molecular Formulas

Molecular Formula

  • C16-H19-N3-S.Cl-H

Molecular Formula Fragments

  • C16-H19-N3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H19N3S.ClH/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19;/h4-10,12H,11H2,1-3H3;1H

InChIKey

RQHCFTORMXCNGP-UHFFFAOYSA-N

Smiles

N1(c2c(Sc3c1nccc3)cccc2)C[C@@H](N(C)C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 41mg/kg (41mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
mouse LD50 intraperitoneal 62mg/kg (62mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
mouse LD50 intravenous 28mg/kg (28mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
mouse LD50 oral 222mg/kg (222mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
mouse LD50 subcutaneous 86mg/kg (86mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
rat LD50 intraperitoneal 206mg/kg (206mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.
rat LD50 oral 1220mg/kg (1220mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
rat LD50 subcutaneous 206mg/kg (206mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.