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Substance Name: Methdilazine hydrochloride [USP]
RN: 1229-35-2
UNII: T0GSO02UEZ
InChIKey: IEISBKIVLDXSMZ-UHFFFAOYSA-N

Classification Codes

  • Antipruritic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C18-H20-N2-S.Cl-H

Molecular Weight

  • 332.8969
 
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Names and Synonyms

Name of Substance

  • Methdilazine hydrochloride
  • Methdilazine hydrochloride [USP]

Synonyms

  • 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine monohydrochloride
  • 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine, hydrochloride
  • 10-(1-Methyl-3-pyrroldiylmethyl)phenothiazine hydrochloride
  • 10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride
  • Bristaline
  • CCRIS 6256
  • Dilosyn
  • Disyncran
  • EINECS 214-967-3
  • HSDB 5192
  • Methdilazine HCl
  • Methdilazine hydrochloride
  • Methdilazine monohydrochloride
  • MJ 5022
  • NSC 169091
  • Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, hydrochloride
  • Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride
  • Tacaryl
  • Tacaryl hydrochloride
  • UNII-T0GSO02UEZ

Systematic Names

  • 10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride
  • Methdilazine hydrochloride
  • Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 1229-35-2

FDA UNII

  • T0GSO02UEZ

Related Registry Number

  • 1982-37-2 (Parent)

System Generated Number

  • 0001229352

Molecular Formulas

Molecular Formula

  • C18-H20-N2-S.Cl-H

Molecular Formula Fragments

  • C18-H20-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H20N2S.ClH/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20;/h2-9,14H,10-13H2,1H3;1H

InChIKey

IEISBKIVLDXSMZ-UHFFFAOYSA-N

Smiles

CN1CCC(C1)CN2c3ccccc3Sc4c2cccc4.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
guinea pig LD50 oral 263mg/kg (263mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LD50 oral 190mg/kg (190mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LDLo intramuscular 300mg/kg (300mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
mouse LDLo intravenous 25mg/kg (25mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
rabbit LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
rat LD50 oral 260mg/kg (260mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
rat LDLo intraperitoneal 75mg/kg (75mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
rat LDLo intravenous 22mg/kg (22mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.