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Substance Name: Hydroquinone [USP]
RN: 123-31-9
UNII: XV74C1N1AE
InChIKey: QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Molecular Formula

  • C6-H6-O2

Molecular Weight

  • 110.1114
 

Classification Codes

Classification Codes

  • Antioxidants
  • Depigmentor
  • Human Data
  • Mutagens
  • Mutation Data
  • Noxae
  • Protective Agents
  • Radiation-Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 100 lb
  • Threshold Planning Quantity (TPQ) = 500/10000 lb
  • TWA 2 mg/m3
  • TWA 2 mg/m3; Confirmed animal carcinogen with unknown relevance to humans

Names and Synonyms

Name of Substance

  • 1,4-Benzenediol
  • Hydroquinone
  • Hydroquinone [USP]
  • p-Hydroxyphenol

Synonyms

  • 1,4-Benzenediol
  • 1,4-Dihydroxy-benzeen
  • 1,4-Dihydroxy-benzeen [Dutch]
  • 1,4-Dihydroxy-benzol
  • 1,4-Dihydroxy-benzol [German]
  • 1,4-Dihydroxybenzen
  • 1,4-Dihydroxybenzen [Czech]
  • 1,4-Dihydroxybenzene
  • 1,4-Diidrobenzene
  • 1,4-Diidrobenzene [Italian]
  • 4-Hydroxyphenol
  • AI3-00072
  • Arctuvin
  • Benzene, p-dihydroxy-
  • Benzohydroquinone
  • Benzoquinol
  • Black and White Bleaching Cream
  • CCRIS 714
  • Derma-Blanch
  • Diak 5
  • EC 204-617-8
  • EINECS 204-617-8
  • Eldopaque
  • Eldopaque Forte
  • Eldoquin
  • Eldoquin Forte
  • Epiquin
  • HE 5
  • Hidroquinone
  • HSDB 577
  • Hydrochinon
  • Hydrochinon [Czech, Polish]
  • Hydroquinol
  • Hydroquinole
  • Hydroquinone
  • Idrochinone
  • Idrochinone [Italian]
  • NCI-C55834
  • NSC 9247
  • p-Benzenediol
  • p-Dihydroxybenzene
  • p-Dioxybenzene
  • p-Hydroquinone
  • p-Hydroxyphenol
  • para-Dihydroxybenzene
  • para-Dioxybenzene
  • para-Hydroquinone
  • Phiaquin
  • Pyrogentistic acid
  • Quinol
  • Solaquin Forte
  • Sunvanish
  • Tecquinol
  • Tenox HQ
  • Tequinol
  • UNII-XV74C1N1AE
  • USAF EK-356

Systematic Names

  • 1,4-Benzenediol
  • Hydroquinone

Superlist Names

  • Dihydroxybenzene
  • Hydroquinone
  • Hydroquinone [UN2662] [Poison]
  • UN2662

Mixture Name

  • Artra

Registry Numbers

CAS Registry Number

  • 123-31-9

FDA UNII

  • XV74C1N1AE

Other Registry Numbers

  • 57534-13-1
  • 8027-02-9

System Generated Number

  • 0000123319

Structure Descriptors

InChI

1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H

InChIKey

QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Smiles

c1(ccc(cc1)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 50mg/kg (50mg/kg)   National Technical Information Service. Vol. OTS0555537,
cat LDLo subcutaneous 50mg/kg (50mg/kg) BEHAVIORAL: TREMOR

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913.
dog LD50 oral 200mg/kg (200mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 8, Pg. 348, 1949.
dog LDLo intravenous 80mg/kg (80mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 162, 1955.
dog LDLo subcutaneous 100mg/kg (100mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 183, Pg. 319, 1936.
frog LDLo parenteral 190mg/kg (190mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
frog LDLo subcutaneous 190mg/kg (190mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 160, 1955.
guinea pig LD50 oral 550mg/kg (550mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 8, Pg. 348, 1949.
guinea pig LDLo intraperitoneal 200mg/kg (200mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 162, 1955.
guinea pig LDLo subcutaneous 300mg/kg (300mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 162, 1955.
human LDLo oral 29mg/kg (29mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 321, 1969.
human TDLo oral 170mg/kg (170mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: COMA
Annales de Medecine Legale. Criminologie, Police Scientifique et Toxicologie. Vol. 7, Pg. 79, 1927.
mammal (species unspecified) LD50 oral 480mg/kg (480mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 136, 1979.
mammal (species unspecified) LD50 skin 5970mg/kg (5970mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   National Technical Information Service. Vol. AD414-344,
mouse LD50 oral 245mg/kg (245mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(8), Pg. 6, 1973.
mouse LD50 subcutaneous 182mg/kg (182mg/kg)   Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. Vol. 2, Pg. 333, 1947.
mouse LD50 unreported 150mg/kg (150mg/kg)   British Journal of Cancer. Vol. 6, Pg. 160, 1952.
pigeon LD50 oral 300mg/kg (300mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 8, Pg. 348, 1949.
rabbit LD50 intraperitoneal 125mg/kg (125mg/kg)   Ecotoxicology and Environmental Safety. Vol. 19, Pg. 327, 1990.
rabbit LD50 oral 200mg/kg (200mg/kg)   International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rabbit LDLo intravenous 100mg/kg (100mg/kg)   Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. Vol. 3, Pg. 311, 1962.
rat LD50 intraperitoneal 170mg/kg (170mg/kg)   Ecotoxicology and Environmental Safety. Vol. 19, Pg. 327, 1990.
rat LD50 intravenous 115mg/kg (115mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 8, Pg. 348, 1949.
rat LD50 oral 302mg/kg (302mg/kg)   National Technical Information Service. Vol. OTS0555537,
rat LD50 unreported 720mg/kg (720mg/kg)   Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. Vol. 8, Pg. 145, 1972.
rat LDLo subcutaneous 300mg/kg (300mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 162, 1955.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 172.3 deg C   EXP
Boiling Point 287 deg C   EXP
pKa Dissociation Constant 10.85 (none) 25 EXP
log P (octanol-water) 0.59 (none)   EXP
Water Solubility 7.20E+04 mg/L 25 EXP
Henry's Law Constant 4.73E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.32E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.