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Substance Name: Teprasiran [USAN]
RN: 1231737-88-4
UNII: O03W5S19PJ
InChIKey: PVVJTTHYHYFHNS-UHFFFAOYSA-N

Classification Code

  • Improving Kidney Function in Transplantation and after Cardiac Surgery

Molecular Formula

  • C380-H484-N140-O262-P36

Molecular Weight

  • 11591.289
 
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Names and Synonyms

Name of Substance

  • Teprasiran
  • Teprasiran [USAN]

Synonyms

  • 15NP
  • I5NP
  • QPI-1002
  • Rna, (g-am-g-am-a-um-a-um-u-um-c-am-c-cm-c-um-u-cm-a), complex with rna (um-g-am-a-gm-g-gm-u-gm-a-am-a-um-a-um-u-cm-u-cm) (1:1)
  • Teprasiran
  • Teprasiran [INN]
  • Teprasiran [WHO-DD]
  • UNII-O03W5S19PJ
  • WHO 10513

Registry Numbers

CAS Registry Number

  • 1231737-88-4

FDA UNII

  • O03W5S19PJ

System Generated Number

  • 1231737884

Structure Descriptors

InChI

1S/C182H224N73O114P19.C169H212N62O110P18.C10H14N5O5P/c183-110-1-9-237(175(268)219-110)118-17-72(256)91(333-118)37-315-371(278,279)353-75-20-121(240-12-4-113(258)222-178(240)271)336-94(75)39-317-373(282,283)354-74-19-119(238-10-2-111(184)220-176(238)269)335-93(74)38-316-374(284,285)355-76-21-122(241-13-5-114(259)223-179(241)272)337-95(76)40-318-375(286,287)356-77-22-123(242-14-6-115(260)224-180(242)273)338-96(77)41-319-378(292,293)359-80-25-126(245-61-208-137-148(185)196-55-202-154(137)245)341-99(80)44-323-376(288,289)357-78-23-124(243-15-7-116(261)225-181(243)274)339-97(78)42-320-379(294,295)360-81-26-127(246-62-209-138-149(186)197-56-203-155(138)246)342-100(81)45-324-381(298,299)361-82-27-128(247-63-210-139-150(187)198-57-204-156(139)247)343-101(82)46-325-382(300,301)362-84-29-130(249-65-212-141-152(189)200-59-206-158(141)249)346-104(84)49-328-386(308,309)367-88-33-134(253-69-216-145-162(253)229-172(193)234-167(145)265)348-106(88)51-329-377(290,291)358-79-24-125(244-16-8-117(262)226-182(244)275)340-98(79)43-321-380(296,297)365-87-32-133(252-68-215-144-161(252)228-171(192)233-166(144)264)350-108(87)53-331-387(310,311)369-90-35-136(255-71-218-147-164(255)231-174(195)236-169(147)267)351-109(90)54-332-388(312,313)368-89-34-135(254-70-217-146-163(254)230-173(194)235-168(146)266)349-107(89)52-330-384(304,305)364-85-30-131(250-66-213-142-153(190)201-60-207-159(142)250)344-102(85)47-326-383(302,303)363-83-28-129(248-64-211-140-151(188)199-58-205-157(140)248)345-103(83)48-327-385(306,307)366-86-31-132(251-67-214-143-160(251)227-170(191)232-165(143)263)347-105(86)50-322-372(280,281)352-73-18-120(334-92(73)36-314-370(276)277)239-11-3-112(257)221-177(239)270;170-107-1-12-214(159(241)199-107)118-23-71(232)89(307-118)41-290-343(255,256)325-76-28-123(219-17-6-112(233)204-164(219)246)312-95(76)47-294-348(265,266)331-78-30-125(221-19-8-114(235)206-166(221)248)313-96(78)48-295-346(261,262)328-73-25-120(216-14-3-109(172)201-161(216)243)309-92(73)44-291-344(257,258)326-72-24-119(215-13-2-108(171)200-160(215)242)308-91(72)43-292-345(259,260)327-74-26-121(217-15-4-110(173)202-162(217)244)311-94(74)46-298-354(277,278)336-83-34-129(225-64-192-136-143(175)182-59-187-148(136)225)319-101(83)53-301-351(271,272)329-75-27-122(218-16-5-111(174)203-163(218)245)310-93(75)45-293-347(263,264)330-77-29-124(220-18-7-113(234)205-165(220)247)314-97(77)49-296-349(267,268)332-79-31-126(222-20-9-115(236)207-167(222)249)315-98(79)50-297-350(269,270)333-80-32-127(223-21-10-116(237)208-168(223)250)316-99(80)51-299-355(279,280)337-84-35-130(226-65-193-137-144(176)183-60-188-149(137)226)320-102(84)54-302-352(273,274)334-81-33-128(224-22-11-117(238)209-169(224)251)317-100(81)52-300-356(281,282)338-85-36-131(227-66-194-138-145(177)184-61-189-150(138)227)322-104(85)56-304-357(283,284)339-87-38-133(229-68-196-140-147(179)186-63-191-152(140)229)323-105(87)57-305-359(287,288)341-88-40-135(231-70-198-142-154(231)211-158(181)213-156(142)240)324-106(88)58-306-358(285,286)340-86-37-132(228-67-195-139-146(178)185-62-190-151(139)228)321-103(86)55-303-353(275,276)335-82-39-134(318-90(82)42-289-342(252,253)254)230-69-197-141-153(230)210-157(180)212-155(141)239;11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(20-7)2-19-21(17)18/h1-16,55-109,118-136,256,370H,17-54H2,(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,296,297)(H,298,299)(H,300,301)(H,302,303)(H,304,305)(H,306,307)(H,308,309)(H,310,311)(H,312,313)(H2,183,219,268)(H2,184,220,269)(H2,185,196,202)(H2,186,197,203)(H2,187,198,204)(H2,188,199,205)(H2,189,200,206)(H2,190,201,207)(H,221,257,270)(H,222,258,271)(H,223,259,272)(H,224,260,273)(H,225,261,274)(H,226,262,275)(H3,191,227,232,263)(H3,192,228,233,264)(H3,193,229,234,265)(H3,194,230,235,266)(H3,195,231,236,267);1-22,59-106,118-135,232H,23-58H2,(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H2,170,199,241)(H2,171,200,242)(H2,172,201,243)(H2,173,202,244)(H2,174,203,245)(H2,175,182,187)(H2,176,183,188)(H2,177,184,189)(H2,178,185,190)(H2,179,186,191)(H,204,233,246)(H,205,234,247)(H,206,235,248)(H,207,236,249)(H,208,237,250)(H,209,238,251)(H2,252,253,254)(H3,180,210,212,239)(H3,181,211,213,240);3-7,16,21H,1-2H2,(H,17,18)(H2,11,12,13)

InChIKey

PVVJTTHYHYFHNS-UHFFFAOYSA-N

Smiles

NC1=Nc2c(ncn2C3CC(OP(=O)(O)OCC4OC(CC4OP(=O)(O)OCC5OC(CC5OP(=O)(O)OCC6OC(CC6OP(=O)(O)OCC7OC(CC7OP(=O)(O)OCC8OC(CC8OP(=O)(O)OCC9OC(CC9OP(=O)(O)OCC%10OC(CC%10OP(=O)(O)OCC%11OC(CC%11OP(=O)(O)OCC%12OC(CC%12OP(=O)(O)OCC%13OC(CC%13OP(=O)(O)OCC%14OC(CC%14OP(=O)(O)OCC%15OC(CC%15O)N%16C=CC(=NC%16=O)N)N%17C=CC(=O)NC%17=O)N%18C=CC(=NC%18=O)N)N%19C=CC(=O)NC%19=O)N%20C=CC(=O)NC%20=O)n%21cnc%22c%21ncnc%22N)N%23C=CC(=O)NC%23=O)n%24cnc%25c%24ncnc%25N)n%26cnc%27c%26ncnc%27N)n%28cnc%29c%28ncnc%29N)n%30cnc%31c%30N=C(N)NC%31=O)N%32C=CC(=O)NC%32=O)C(COP(=O)(O)OC%33CC(OC%33COP(=O)(O)OC%34CC(OC%34COP(=O)(O)OC%35CC(OC%35COP(=O)(O)OC%36CC(OC%36COP(=O)(O)OC%37CC(OC%37COP(=O)(O)OC%38CC(OC%38COP(=O)O)N%39C=CC(=O)NC%39=O)n%40cnc%41c%40N=C(N)NC%41=O)n%42cnc%43c%42ncnc%43N)n%44cnc%45c%44ncnc%45N)n%46cnc%47c%46N=C(N)NC%47=O)n%48cnc%49c%48N=C(N)NC%49=O)O3)C(=O)N1.NC%50=Nc%51c(ncn%51C%52CC(OP(=O)(O)OCC%53OC(CC%53OP(=O)(O)OCC%54OC(CC%54OP(=O)(O)OCC%55OC(CC%55OP(=O)(O)OCC%56OC(CC%56OP(=O)(O)OCC%57OC(CC%57OP(=O)(O)OCC%58OC(CC%58OP(=O)(O)OCC%59OC(CC%59OP(=O)(O)OCC%60OC(CC%60OP(=O)(O)OCC%61OC(CC%61OP(=O)(O)OCC%62OC(CC%62OP(=O)(O)OCC%63OC(CC%63OP(=O)(O)OCC%64OC(CC%64OP(=O)(O)OCC%65OC(CC%65OP(=O)(O)OCC%66OC(CC%66OP(=O)(O)OCC%67OC(CC%67O)N%68C=CC(=NC%68=O)N)N%69C=CC(=O)NC%69=O)N%70C=CC(=O)NC%70=O)N%71C=CC(=NC%71=O)N)N%72C=CC(=NC%72=O)N)N%73C=CC(=NC%73=O)N)n%74cnc%75c%74ncnc%75N)N%76C=CC(=NC%76=O)N)N%77C=CC(=O)NC%77=O)N%78C=CC(=O)NC%78=O)N%79C=CC(=O)NC%79=O)n%80cnc%81c%80ncnc%81N)N%82C=CC(=O)NC%82=O)n%83cnc%84c%83ncnc%84N)n%85cnc%86c%85ncnc%86N)C(COP(=O)(O)OC%87CC(OC%87COP(=O)(O)OC%88CC(OC%88COP(=O)(O)O)n%89cnc%90c%89N=C(N)NC%90=O)n%91cnc%92c%91ncnc%92N)O%52)C(=O)N%50.Nc%93ncnc%94c%93ncn%94C%95CC(O)C(COP(=O)O)O%95