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Substance Name: Abemaciclib [USAN:INN]
RN: 1231929-97-7
UNII: 60UAB198HK
InChIKey: UZWDCWONPYILKI-UHFFFAOYSA-N

Note

  • A cell cycle inhibitor.

    NCI: An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. NCI Thesaurus)

Molecular Formula

  • C27-H32-F2-N8

Molecular Weight

  • 506.6018
 

Classification Code

  • Treatment of Advanced Cancer

Names and Synonyms

Name of Substance

  • Abemaciclib [USAN:INN]

Synonyms

  • 2-Pyrimidinamine, N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)
  • Abemaciclib
  • LY 2835219
  • LY-2835219
  • UNII-60UAB198HK
  • Verzenio

Registry Numbers

CAS Registry Number

  • 1231929-97-7

FDA UNII

  • 60UAB198HK

System Generated Number

  • 1231929977

Structure Descriptors

InChI

1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)

InChIKey

UZWDCWONPYILKI-UHFFFAOYSA-N

Smiles

CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)c4cc(F)c5nc(C)n(C(C)C)c5c4)nc2)CC1