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Substance Name: Clofarabine [USAN:INN:BAN]
RN: 123318-82-1
UNII: 762RDY0Y2H
InChIKey: WDDPHFBMKLOVOX-AYQXTPAHSA-N

Note

  • Approved in the United States for treatment of acute lymphoblastic leukaemia in paediatric patients who have relapsed.

Molecular Formula

  • C10-H11-Cl-F-N5-O3

Molecular Weight

  • 303.6799
 

Classification Codes

  • Antimetabolites
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Mutation Data
  • Noxae
  • Treatment of Primary Refractory or Relapsed Acute Myelogenous Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL) in Pediatric and Adult Patients

Names and Synonyms

Name of Substance

  • Clofarabine
  • Clofarabine [USAN:INN:BAN]

Synonyms

  • 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
  • C1-F-Ara-A
  • Clofarabine
  • Clofarex
  • Clolar
  • Evoltra
  • UNII-762RDY0Y2H

Systematic Names

  • 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
  • 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-

Registry Numbers

CAS Registry Number

  • 123318-82-1

FDA UNII

  • 762RDY0Y2H

System Generated Number

  • 0123318821

Structure Descriptors

InChI

1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

InChIKey

WDDPHFBMKLOVOX-AYQXTPAHSA-N

Smiles

c1nc2c(nc(nc2n1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N