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Substance Name: Arteflene [USAN:INN]
RN: 123407-36-3
UNII: 5PE5HV9NF0
InChIKey: LRTRTVPZZJAADL-DAHZFVMQSA-N

Classification Codes

  • Anti-Infective Agents
  • Antimalarial
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H18-F6-O3

Molecular Weight

  • 408.3362
 
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Names and Synonyms

Name of Substance

  • Arteflene
  • Arteflene [USAN:INN]

Synonyms

  • (1S,4R,5R,8S)-4-((Z)-2,4-Bis(trifluoromethyl)styryl)-4,8-dimethyl-2,3-dioxabicyclo(3.3.1)nonan-7-one
  • 2,3-Dioxabicyclo(3.3.1)nonan-7-one, 4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8-dimethyl-(1S-(1alpha,4beta(Z),5alpha,8beta))-
  • Arteflene
  • Ro 42-1611
  • UNII-5PE5HV9NF0

Systematic Name

  • 2,3-Dioxabicyclo(3.3.1)nonan-7-one, 4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8-dimethyl-(1S-(1alpha,4beta(Z),5alpha,8beta))-

Registry Numbers

CAS Registry Number

  • 123407-36-3

FDA UNII

  • 5PE5HV9NF0

System Generated Number

  • 0123407363

Structure Descriptors

InChI

1S/C19H18F6O3/c1-10-15(26)8-13-9-16(10)27-28-17(13,2)6-5-11-3-4-12(18(20,21)22)7-14(11)19(23,24)25/h3-7,10,13,16H,8-9H2,1-2H3/b6-5-/t10-,13+,16+,17+/m1/s1

InChIKey

LRTRTVPZZJAADL-DAHZFVMQSA-N

Smiles

C[C@H]1[C@@H]2C[C@H](CC1=O)[C@@](C)(OO2)\C=C/c3ccc(cc3C(F)(F)F)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Tropenmedizin und Parasitologie. Vol. 45, Pg. 261, 1994.
mouse LD subcutaneous > 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Tropenmedizin und Parasitologie. Vol. 45, Pg. 261, 1994.
rat LD oral > 1gm/kg (1000mg/kg)   Tropenmedizin und Parasitologie. Vol. 45, Pg. 261, 1994.
rat LD subcutaneous > 1gm/kg (1000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Tropenmedizin und Parasitologie. Vol. 45, Pg. 261, 1994.