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Substance Name: Prulifloxacin [INN]
RN: 123447-62-1
UNII: J42298IESW
InChIKey: PWNMXPDKBYZCOO-UHFFFAOYSA-N

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Molecular Formula

  • C21-H20-F-N3-O6-S

Molecular Weight

  • 461.468
 
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Names and Synonyms

Name of Substance

  • Prulifloxacin
  • Prulifloxacin [INN]

Synonyms

  • (+-)-7-(4-((Z)-2,3-Dihydroxy-2-butenyl)-1-piperazinyl)-6-fluoro-1-methyl-4-oxo-1H,4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid, cyclic carbonate
  • CCRIS 7686
  • NM 441
  • NM-441
  • NM441
  • Prulifloxacin
  • UNII-J42298IESW

Systematic Names

  • 1H,4H-(1,3)Thiazeto(3,2-a)quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-1-piperazinyl)-4-oxo-
  • Prulifloxacin

Registry Numbers

CAS Registry Number

  • 123447-62-1

FDA UNII

  • J42298IESW

System Generated Number

  • 0123447621

Structure Descriptors

InChI

1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)

InChIKey

PWNMXPDKBYZCOO-UHFFFAOYSA-N

Smiles

o1c(oc(CN2CCN(CC2)c2c(cc3c(c2)n2c(c(c3=O)C(O)=O)S[C@@H]2C)F)c1C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Toxicological Sciences. Vol. 21(Suppl,
mouse LD subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of Toxicological Sciences. Vol. 21(Suppl,
mouse LD50 intraperitoneal 1652mg/kg (1652mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Journal of Toxicological Sciences. Vol. 21(Suppl,
mouse LD50 oral > 5gm/kg (5000mg/kg)   Journal of Medicinal Chemistry. Vol. 35, Pg. 4727, 1992.
rat LD oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Toxicological Sciences. Vol. 21(Suppl,
rat LD subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of Toxicological Sciences. Vol. 21(Suppl,
rat LD50 intraperitoneal 915mg/kg (915mg/kg)   Journal of Toxicological Sciences. Vol. 21(Suppl,
rat LD50 intraperitoneal 915mg/kg (915mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Journal of Toxicological Sciences. Vol. 21(Suppl,