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Substance Name: TRV 120027
RN: 1234510-46-3
UNII: J1J4P3PQZD
InChIKey: XIEWFECSPPTVQN-KMIMAYJXSA-N

Note

  • A beta-arrestin biased ligand of the angiotensin II type 1 receptor that competitively antagonizes angiotensin II-stimulated G protein signaling, but stimulates ?-arrestin recruitment and activates several kinase pathways.

Molecular Formula

  • C43-H67-N13-O10

Molecular Weight

  • 926.0833
 
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Names and Synonyms

Results Name

  • TRV 120027

Name of Substance

  • TRV-120027

Synonyms

  • TRV120027
  • UNII-J1J4P3PQZD

Systematic Name

  • D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-

Registry Numbers

CAS Registry Number

  • 1234510-46-3

FDA UNII

  • J1J4P3PQZD

System Generated Number

  • 1234510463

Structure Descriptors

InChI

1S/C43H67N13O10/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48)/t24-,25+,29-,30-,31-,32-,34-,35-/m0/s1

InChIKey

XIEWFECSPPTVQN-KMIMAYJXSA-N

Smiles

CC[C@H](C)[C@@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)NC(=O)[C@H](Cc3ccc(cc3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC