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Substance Name: Biperiden hydrochloride [USP:BAN:JAN]
RN: 1235-82-1
UNII: K35N76CUHF
InChIKey: RDNLAULGBSQZMP-UHFFFAOYSA-N

Note

  • A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.

Molecular Formula

  • C21-H29-N-O.Cl-H

Molecular Weight

  • 347.927
 

Classification Codes

  • Anticholinergic
  • Antiparkinsonian
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Biperiden hydrochloride [USP:BAN:JAN]

Synonyms

  • 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol-1 hydrochloride
  • 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-, hydrochloride
  • Akineton
  • Akineton hydrochloride
  • Akinophyl
  • alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinepropanol hydrochloride
  • alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol hydrochloride
  • Biperiden HCl
  • Biperiden hydrochloride
  • EINECS 214-976-2
  • NSC 170950
  • NSC 84989
  • Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-, hydrochloride
  • UNII-K35N76CUHF

Systematic Names

  • 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl-, hydrochloride
  • 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-, hydrochloride
  • Biperiden hydrochloride

Registry Numbers

CAS Registry Number

  • 1235-82-1

FDA UNII

  • K35N76CUHF

Related Registry Number

  • 514-65-8 (Parent)

System Generated Number

  • 0001235821

Molecular Formulas

Molecular Formula

  • C21-H29-N-O.Cl-H

Molecular Formula Fragments

  • C21-H29-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H

InChIKey

RDNLAULGBSQZMP-UHFFFAOYSA-N

Smiles

C1N(CC[C@@]([C@@H]2C[C@@H]3C=C[C@@H]2C3)(O)c2ccccc2)CCCC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 340mg/kg (340mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Toxicology and Applied Pharmacology. Vol. 2, Pg. 379, 1960.
mouse LD50 intravenous 56mg/kg (56mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 192, 1989.
mouse LD50 oral 530mg/kg (530mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967.
rat LD50 oral 750mg/kg (750mg/kg) BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Toxicology and Applied Pharmacology. Vol. 2, Pg. 379, 1960.