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Substance Name: Levomepromazine hydrochloride [USAN:JAN]
RN: 1236-99-3
UNII: 42BB1Y2586
InChIKey: ODLGFPIWRAEFAN-PFEQFJNWSA-N

Notes

  • A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine.
  • A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Molecular Formula

  • C19-H24-N2-O-S.Cl-H

Molecular Weight

  • 364.9385
 

Classification Codes

  • Analgesic (Central Nervous System Depressant)
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Levomepromazine hydrochloride [USAN:JAN]
  • Nozinan [USAN]

Synonyms

  • (2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine hydrochloride
  • 10-(3-Dimethylamino-2-methylpropyl)-2-methoxyphenothiazine hydrochloride
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, monohydrochloride, (betaR)-
  • 7044 RP hydrochloride
  • EINECS 214-978-3
  • Levomepromazine HCl
  • Levomepromazine hydrochloride
  • Levomepromazinium chloride
  • Levopromazine hydrochloride
  • Methoxy-3 (dimethylamino-3 methyl-2 propyl)-10 phenothiazine hydrochloride
  • Neurocil
  • Nozinan
  • Nozinan hydrochloride
  • UNII-42BB1Y2586

Systematic Names

  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, monohydrochloride, (R)- (9CI)
  • Levomepromazine hydrochloride
  • Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-2-methoxy-, hydrochloride

Registry Numbers

CAS Registry Number

  • 1236-99-3

FDA UNII

  • 42BB1Y2586

System Generated Number

  • 0001236993

Molecular Formulas

Molecular Formula

  • C19-H24-N2-O-S.Cl-H

Molecular Formula Fragments

  • C19-H24-N2-O-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H24N2OS.ClH/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21;/h5-11,14H,12-13H2,1-4H3;1H/t14-;/m1./s1

InChIKey

ODLGFPIWRAEFAN-PFEQFJNWSA-N

Smiles

C[C@@H](CN1c2ccccc2Sc3c1cc(cc3)OC)CN(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 135mg/kg (135mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 160, Pg. 1852, 1966.
mouse LD50 intravenous 75mg/kg (75mg/kg) BEHAVIORAL: SLEEP Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962.
mouse LD50 oral 380mg/kg (380mg/kg)   Cesko-Slovenska Farmacie. Vol. 15, Pg. 455, 1966.
mouse LD50 subcutaneous 360mg/kg (360mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 155, Pg. 1029, 1961.