Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Pimasertib hydrochloride [USAN]
RN: 1236361-78-6
UNII: 6GS1ULF5HV
InChIKey: HIEXZUXKTABHCP-PPHPATTJSA-N

Note

  • NCI: An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. (NCI Thesaurus)

Molecular Weight

  • 467.6604
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Pimasertib hydrochloride [USAN]

Name of Substance

  • Pimasertib hydrochloride
  • Pimasertib hydrochloride [USAN]

Synonyms

  • 4-Pyridinecarboxamide, N-((2S)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)-, hydrochloride (1:1)
  • MSC 1936369B
  • MSC-1936369B
  • MSC1936369B
  • Pimasertib hydrochloride
  • UNII-6GS1ULF5HV

Systematic Name

  • 4-Pyridinecarboxamide, N-((2S)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)-, hydrochloride (1:1)

Registry Numbers

CAS Registry Number

  • 1236361-78-6

FDA UNII

  • 6GS1ULF5HV

System Generated Number

  • 1236361786

Structure Descriptors

InChI

1S/C15H15FIN3O3.ClH/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21;/h1-5,7,10,20-22H,6,8H2,(H,19,23);1H/t10-;/m0./s1

InChIKey

HIEXZUXKTABHCP-PPHPATTJSA-N

Smiles

c1cc(c(cc1I)F)Nc2cnccc2C(=O)NC[C@@H](CO)O.Cl