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Substance Name: Pimasertib [USAN:INN]
RN: 1236699-92-5
UNII: 6ON9RK82AL
InChIKey: VIUAUNHCRHHYNE-JTQLQIEISA-N

Note

  • A MEK1/2 inhibitor.

    NCI:An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. (NCI Thesaurus)

Molecular Weight

  • 431.1995
 
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Names and Synonyms

Name of Substance

  • Pimasertib [USAN:INN]

Synonyms

  • 4-Pyridinecarboxamide, N-((2S)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)-
  • AS 703026
  • As-703026
  • MSC1936369B
  • N-((2S)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)pyridine-4-carboxamide
  • Pimasertib
  • UNII-6ON9RK82AL

Registry Numbers

CAS Registry Number

  • 1236699-92-5

FDA UNII

  • 6ON9RK82AL

System Generated Number

  • 1236699925

Structure Descriptors

InChI

1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1

InChIKey

VIUAUNHCRHHYNE-JTQLQIEISA-N