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Substance Name: Sargramostim [USAN:USP:INN:BAN:JAN]
RN: 123774-72-1
UNII: 5TAA004E22
InChIKey: GIFLSXMSRXLWKH-DJZQXEJWSA-N

Note

  • A glycosylated form of recombinant GM-CSF; used to treat drug-induced agranulocytosis.

Classification Codes

  • Antineutropenic
  • Hematopoietic Stimulant

Molecular Formula

  • C639-H1002-N168-O196-S8

Molecular Weight

  • 14430.4528
 

Names and Synonyms

Name of Substance

  • Sargramostim
  • Sargramostim [USAN:USP:INN:BAN:JAN]

Synonyms

  • 23-L-Leucinecolony-stimulating factor 2 (human clone pHG25 protein moiety)
  • B1 61.012
  • Granulocyte-macrophage colony stimulating factor, recombinant
  • Leukine
  • Mielogen
  • Prokine
  • Recombinant human granulocyte-macrophage colony stimulating factor
  • rGM-CSF
  • rHu GM-CSF
  • Sargramostim
  • UNII-5TAA004E22

Systematic Name

  • Colony-stimulating factor 2 (human clone pHG25 protein moiety), 23-L-leucine-

Registry Numbers

CAS Registry Number

  • 123774-72-1

FDA UNII

  • 5TAA004E22

System Generated Number

  • 0123774721

Structure Descriptors

InChI

1S/C639H1002N168O196S8/c1-74-321(46)495(781-516(884)332(57)688-550(918)426(269-466(655)838)763-607(975)490(316(36)37)777-583(951)425(268-356-281-671-300-684-356)750-539(907)386(183-204-478(855)856)712-570(938)422(265-353-278-678-362-139-97-95-137-360(353)362)761-598(966)449-153-117-229-799(449)625(993)395(177-198-465(654)837)728-619(987)505(339(64)822)793-591(959)440(291-814)767-600(968)450-154-118-232-802(450)629(997)442(293-816)771-601(969)451-155-119-233-803(451)628(996)441(292-815)770-531(899)370(147-111-223-673-636(661)662)694-513(881)331(56)690-595(963)448-152-116-228-798(448)624(992)326(51)646)610(978)723-377(173-194-461(650)833)532(900)706-381(178-199-473(845)846)521(889)686-329(54)514(882)730-400(243-302(8)9)552(920)702-371(148-112-224-674-637(663)664)528(896)733-406(249-308(20)21)558(926)735-409(252-311(26)27)561(929)754-429(272-469(658)841)576(944)738-410(253-312(28)29)562(930)766-436(287-810)586(954)703-372(149-113-225-675-638(665)666)529(897)756-433(276-489(877)878)584(952)790-500(334(59)817)614(982)691-327(52)511(879)685-328(53)512(880)695-382(179-200-474(847)848)533(901)716-393(214-240-1006-72)544(912)753-427(270-467(656)839)574(942)713-388(185-206-480(859)860)548(916)789-509(343(68)826)623(991)780-492(318(40)41)606(974)722-390(187-208-482(863)864)545(913)776-493(319(42)43)608(976)783-496(322(47)75-2)611(979)768-438(289-812)587(955)714-383(180-201-475(849)850)534(902)717-392(213-239-1005-71)543(911)743-415(258-346-128-86-80-87-129-346)568(936)757-431(274-487(873)874)577(945)739-404(247-306(16)17)556(924)708-375(171-192-459(648)831)535(903)726-396(188-209-483(865)866)626(994)801-231-121-159-455(801)603(971)794-507(341(66)824)622(990)774-445-296-1009-1008-294-443-592(960)689-333(58)517(885)786-501(335(60)818)615(983)724-380(176-197-464(653)836)546(914)782-497(323(48)76-3)612(980)784-498(324(49)77-4)613(981)795-508(342(67)825)620(988)762-420(261-349-134-92-83-93-135-349)566(934)711-387(184-205-479(857)858)541(909)765-437(288-811)589(957)747-414(257-345-126-84-79-85-127-345)563(931)700-367(143-101-107-219-643)525(893)707-384(181-202-476(851)852)540(908)752-428(271-468(657)840)575(943)737-403(246-305(14)15)554(922)698-368(144-102-108-220-644)526(894)755-430(273-486(871)872)578(946)746-416(259-347-130-88-81-89-131-347)567(935)736-408(251-310(24)25)559(927)740-411(254-313(30)31)580(948)778-494(320(44)45)609(977)785-499(325(50)78-5)632(1000)805-235-123-157-453(805)599(967)760-419(260-348-132-90-82-91-133-348)569(937)758-432(275-488(875)876)579(947)772-444(593(961)748-421(264-352-277-677-361-138-96-94-136-359(352)361)571(939)727-397(189-210-484(867)868)627(995)800-230-120-158-454(800)602(970)779-491(317(38)39)605(973)721-378(174-195-462(651)834)536(904)729-398(634(1002)1003)190-211-485(869)870)295-1010-1011-297-446(630(998)807-237-125-161-457(807)631(999)804-234-122-160-456(804)604(972)796-510(344(69)827)633(1001)806-236-124-156-452(806)597(965)718-389(186-207-481(861)862)549(917)788-506(340(65)823)621(989)769-439(290-813)590(958)773-443)775-573(941)424(267-355-280-670-299-683-355)749-537(905)376(172-193-460(649)832)705-524(892)366(142-100-106-218-642)701-565(933)418(263-351-164-168-358(829)169-165-351)745-572(940)423(266-354-279-669-298-682-354)751-588(956)435(286-809)764-515(883)330(55)687-522(890)391(212-238-1004-70)715-542(910)394(215-241-1007-73)725-618(986)504(338(63)821)792-582(950)413(256-315(34)35)759-596(964)447-151-115-227-797(447)472(844)284-681-519(887)363(140-98-104-216-640)696-553(921)401(244-303(10)11)731-527(895)369(145-103-109-221-645)719-617(985)503(337(62)820)791-581(949)412(255-314(32)33)741-585(953)434(285-808)693-471(843)283-679-518(886)364(146-110-222-672-635(659)660)697-551(919)399(242-301(6)7)692-470(842)282-680-520(888)374(170-191-458(647)830)704-523(891)365(141-99-105-217-641)699-564(932)417(262-350-162-166-357(828)167-163-350)744-560(928)407(250-309(22)23)734-538(906)385(182-203-477(853)854)710-555(923)402(245-304(12)13)732-530(898)373(150-114-226-676-639(667)668)720-616(984)502(336(61)819)787-547(915)379(175-196-463(652)835)709-557(925)405(248-307(18)19)742-594(445)962/h79-97,126-139,162-169,277-281,298-344,363-457,490-510,677-678,808-829H,74-78,98-125,140-161,170-276,282-297,640-646H2,1-73H3,(H2,647,830)(H2,648,831)(H2,649,832)(H2,650,833)(H2,651,834)(H2,652,835)(H2,653,836)(H2,654,837)(H2,655,838)(H2,656,839)(H2,657,840)(H2,658,841)(H,669,682)(H,670,683)(H,671,684)(H,679,886)(H,680,888)(H,681,887)(H,685,879)(H,686,889)(H,687,890)(H,688,918)(H,689,960)(H,690,963)(H,691,982)(H,692,842)(H,693,843)(H,694,881)(H,695,880)(H,696,921)(H,697,919)(H,698,922)(H,699,932)(H,700,931)(H,701,933)(H,702,920)(H,703,954)(H,704,891)(H,705,892)(H,706,900)(H,707,893)(H,708,924)(H,709,925)(H,710,923)(H,711,934)(H,712,938)(H,713,942)(H,714,955)(H,715,910)(H,716,901)(H,717,902)(H,718,965)(H,719,985)(H,720,984)(H,721,973)(H,722,974)(H,723,978)(H,724,983)(H,725,986)(H,726,903)(H,727,939)(H,728,987)(H,729,904)(H,730,882)(H,731,895)(H,732,898)(H,733,896)(H,734,906)(H,735,926)(H,736,935)(H,737,943)(H,738,944)(H,739,945)(H,740,927)(H,741,953)(H,742,962)(H,743,911)(H,744,928)(H,745,940)(H,746,946)(H,747,957)(H,748,961)(H,749,905)(H,750,907)(H,751,956)(H,752,908)(H,753,912)(H,754,929)(H,755,894)(H,756,897)(H,757,936)(H,758,937)(H,759,964)(H,760,967)(H,761,966)(H,762,988)(H,763,975)(H,764,883)(H,765,909)(H,766,930)(H,767,968)(H,768,979)(H,769,989)(H,770,899)(H,771,969)(H,772,947)(H,773,958)(H,774,990)(H,775,941)(H,776,913)(H,777,951)(H,778,948)(H,779,970)(H,780,991)(H,781,884)(H,782,914)(H,783,976)(H,784,980)(H,785,977)(H,786,885)(H,787,915)(H,788,917)(H,789,916)(H,790,952)(H,791,949)(H,792,950)(H,793,959)(H,794,971)(H,795,981)(H,796,972)(H,845,846)(H,847,848)(H,849,850)(H,851,852)(H,853,854)(H,855,856)(H,857,858)(H,859,860)(H,861,862)(H,863,864)(H,865,866)(H,867,868)(H,869,870)(H,871,872)(H,873,874)(H,875,876)(H,877,878)(H,1002,1003)(H4,659,660,672)(H4,661,662,673)(H4,663,664,674)(H4,665,666,675)(H4,667,668,676)/t321-,322-,323-,324-,325-,326-,327-,328-,329-,330-,331-,332-,333-,334+,335+,336+,337+,338+,339+,340+,341+,342+,343+,344+,363-,364-,365-,366-,367-,368-,369-,370-,371-,372-,373-,374-,375-,376-,377-,378-,379-,380-,381-,382-,383-,384-,385-,386-,387-,388-,389-,390-,391-,392-,393-,394-,395-,396-,397-,398-,399-,400-,401-,402-,403-,404-,405-,406-,407-,408-,409-,410-,411-,412-,413-,414-,415-,416-,417-,418-,419-,420-,421-,422-,423-,424-,425-,426-,427-,428-,429-,430-,431-,432-,433-,434-,435-,436-,437-,438-,439-,440-,441-,442-,443-,444-,445-,446-,447-,448-,449-,450-,451-,452-,453-,454-,455-,456-,457-,490-,491-,492-,493-,494-,495-,496-,497-,498-,499-,500-,501-,502-,503-,504-,505-,506-,507-,508-,509-,510-/m0/s1

InChIKey

GIFLSXMSRXLWKH-DJZQXEJWSA-N