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Substance Name: Homidium bromide [INN:BAN]
RN: 1239-45-8
UNII: 059NUO2Z1L
InChIKey: ZMMJGEGLRURXTF-UHFFFAOYSA-N

Note

  • /Ethidium/ A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.

Molecular Formulas

  • C21-H20-Br-N3
  • C21-H20-N3.Br

Molecular Weight

  • 394.314
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data

Names and Synonyms

Name of Substance

  • Homidium bromide [INN:BAN]

Synonyms

  • 2,7-Diamino-10-ethyl-9-phenylphenanthridinium bromide
  • 2,7-Diamino-9-phenyl-10-ethylphenanthridinium bromide
  • 2,7-Diamino-9-phenylphenanthridine ethobromide
  • 3,8-Diamino-5-ethyl-6-phenylphenanthridinium bromide
  • AI3-62997
  • Bromure d'homidium
  • Bromure d'homidium [INN-French]
  • Bromuro de homidio
  • Bromuro de homidio [INN-Spanish]
  • CCRIS 1017
  • Dromilac
  • EINECS 214-984-6
  • Ethidium bromide
  • Ethydium bromide
  • Homidii bromidum
  • Homidii bromidum [INN-Latin]
  • Homidium bromide
  • HSDB 7297
  • NSC 268986
  • RD 1572
  • UNII-059NUO2Z1L

Systematic Names

  • 3,8-Diamino-1-ethyl-6-phenylphenantridinium bromide
  • 3,8-Diamino-5-ethyl-6-phenylphenanthridinium bromide
  • Ethidium bromide
  • Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-, bromide

Registry Numbers

CAS Registry Number

  • 1239-45-8

FDA UNII

  • 059NUO2Z1L

Other Registry Numbers

  • 131089-24-2
  • 35322-47-5

System Generated Number

  • 0001239458

Molecular Formulas

Molecular Formulas

  • C21-H20-Br-N3
  • C21-H20-N3.Br

Molecular Formula Fragments

  • Br
  • C21-H20-N3
  • COMPONENT

Structure Descriptors

InChI

1S/C21H19N3.BrH/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14;/h3-13,23H,2,22H2,1H3;1H

InChIKey

ZMMJGEGLRURXTF-UHFFFAOYSA-N

Smiles

c1(c2c(c3ccc(cc3[n+]1CC)N)ccc(c2)N)c1ccccc1.[BrH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 110mg/kg (110mg/kg)   Annals of Tropical Medicine and Parasitology. Vol. 46, Pg. 285, 1952.
mouse LDLo intraperitoneal 20mg/kg (20mg/kg)   Cancer Research. Vol. 34, Pg. 2699, 1974.