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Substance Name: Topotecan [INN:BAN]
RN: 123948-87-8
UNII: 7M7YKX2N15
InChIKey: UCFGDBYHRUNTLO-QHCPKHFHSA-N

Note

  • An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

Molecular Formula

  • C23-H23-N3-O5

Molecular Weight

  • 421.4507
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Topoisomerase I Inhibitors
  • Topoisomerase Inhibitors

Names and Synonyms

Name of Substance

  • Topotecan
  • Topotecan [INN:BAN]

MeSH Heading

  • Topotecan

Synonyms

  • (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
  • (S)-Topotecan
  • CCRIS 8163
  • HSDB 8213
  • Hycamptamine
  • Hycamtin
  • Nogitecan
  • NSC 609699
  • NSC609699
  • SK&F 104864 A
  • SK&F-104864-A
  • SKF-104864-A
  • TopoCED
  • Topophore C
  • Topotecan
  • Topotecan Actavis
  • Topotecan lactone
  • Topotecane
  • Topotecane [INN-French]
  • Topotecanum
  • Topotecanum [INN-Latin]
  • UNII-7M7YKX2N15

Systematic Name

  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-, (S)-

Registry Numbers

CAS Registry Number

  • 123948-87-8

FDA UNII

  • 7M7YKX2N15

Other Registry Numbers

  • 133242-28-1
  • 138121-88-7

System Generated Number

  • 0123948878

Structure Descriptors

InChI

1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

InChIKey

UCFGDBYHRUNTLO-QHCPKHFHSA-N

Smiles

CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccc(c(c5c4)CN(C)C)O)O

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.880 (none)   EST
Atmospheric OH Rate Constant 2.92E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.