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Substance Name: Spermidine
RN: 124-20-9
UNII: U87FK77H25
InChIKey: ATHGHQPFGPMSJY-UHFFFAOYSA-N
Note
- A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
Molecular Formula
- C7-H19-N3
Molecular Weight
- 145.248
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Classification Codes
- Drug / Therapeutic Agent
- Mutation Data
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Names and Synonyms
Name of Substance
- Spermidine
MeSH Heading
- Spermidine
Synonyms
- 1,4-Diaminobutane, N-(3-aminopropyl)-
- 1,5,10-Triazadecane
- 4-04-00-01300 (Beilstein Handbook Reference)
- AI3-26636
- BRN 1698591
- EINECS 204-689-0
- Spermidine
- UNII-U87FK77H25
Systematic Names
- 1,4-Butanediamine, N-(3-aminopropyl)-
- 1,4-Butanediamine, N1-(3-aminopropyl)-
- 4-Azaoctamethylenediamine
Registry Numbers
CAS Registry Number
- 124-20-9
FDA UNII
- U87FK77H25
System Generated Number
- 0000124209
Structure Descriptors
InChI
InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2InChIKey
ATHGHQPFGPMSJY-UHFFFAOYSA-NSmiles
NCCCCNCCCNToxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD30 | oral | > 1gm/kg (1000mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984. | |
mouse | LD30 | subcutaneous | 450mg/kg (450mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984. |
mouse | LD50 | intravenous | 78mg/kg (78mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 198, Pg. 36, 1972. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | < 25 | deg C | EXP | |
log P (octanol-water) | -0.660 | (none) | EST | |
Atmospheric OH Rate Constant | 1.52E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.