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Substance Name: Spermidine
RN: 124-20-9
UNII: U87FK77H25
InChIKey: ATHGHQPFGPMSJY-UHFFFAOYSA-N

Note

  • A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.

Molecular Formula

  • C7-H19-N3

Molecular Weight

  • 145.248
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Spermidine

MeSH Heading

  • Spermidine

Synonyms

  • 1,4-Diaminobutane, N-(3-aminopropyl)-
  • 1,5,10-Triazadecane
  • 4-04-00-01300 (Beilstein Handbook Reference)
  • AI3-26636
  • BRN 1698591
  • EINECS 204-689-0
  • Spermidine
  • UNII-U87FK77H25

Systematic Names

  • 1,4-Butanediamine, N-(3-aminopropyl)-
  • 1,4-Butanediamine, N1-(3-aminopropyl)-
  • 4-Azaoctamethylenediamine

Registry Numbers

CAS Registry Number

  • 124-20-9

FDA UNII

  • U87FK77H25

System Generated Number

  • 0000124209

Structure Descriptors

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChIKey

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Smiles

C(NCCCN)CCCN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD30 oral > 1gm/kg (1000mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984.
mouse LD30 subcutaneous 450mg/kg (450mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Agents and Actions, A Swiss Journal of Pharmacology. Vol. 14, Pg. 228, 1984.
mouse LD50 intravenous 78mg/kg (78mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 198, Pg. 36, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) -0.660 (none)   EST
Atmospheric OH Rate Constant 1.52E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.