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Substance Name: Triamcinolone [USP:INN:BAN:JAN]
RN: 124-94-7
UNII: 1ZK20VI6TY
InChIKey: GFNANZIMVAIWHM-OBYCQNJPSA-N

Note

  • A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

Molecular Formula

  • C21-H27-F-O6

Molecular Weight

  • 394.436
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Triamcinolone
  • Triamcinolone [USP:INN:BAN:JAN]

MeSH Heading

  • Triamcinolone

Synonyms

  • 11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
  • 4-08-00-03629 (Beilstein Handbook Reference)
  • 9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9-alpha-Fluoro-16-alpha-hydroxyprednisolone
  • 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9alpha-Fluoro-16alpha-hydroxyprednisolone
  • Adcortyl
  • Aristocort
  • Aristocort Tablets
  • BRN 2341955
  • Celeste
  • Cinolone-T
  • CL 19823
  • Delphicort
  • EINECS 204-718-7
  • Fluoxyprednisolone
  • HSDB 3194
  • Kenacort
  • Kenacort-AG
  • Ledercort
  • Mycolog
  • NSC 13397
  • Omcilon
  • Orion
  • Polcortolon
  • Prednisolone, 9-fluoro-16alpha-hydroxy-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11-beta,16-alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy-
  • Rodinolone
  • SK-Triamcinolone
  • Tiamcinolonum
  • Tiamcinolonum [INN-Latin]
  • Triam-Tablinen
  • Triamcet
  • Triamcinolon
  • Triamcinolona
  • Triamcinolona [INN-Spanish]
  • Triamcinolone
  • Triamcinolonum
  • Triamcinolonum [INN]
  • Tricortale
  • UNII-1ZK20VI6TY
  • Volon

Systematic Names

  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
  • Triamcinolone

Registry Numbers

CAS Registry Number

  • 124-94-7

FDA UNII

  • 1ZK20VI6TY

Other Registry Number

  • 83474-03-7

System Generated Number

  • 0000124947

Structure Descriptors

InChI

1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1

InChIKey

GFNANZIMVAIWHM-OBYCQNJPSA-N

Smiles

F[C@]12[C@H]([C@H]3[C@]([C@](C(CO)=O)(O)[C@@H](C3)O)(C)C[C@@H]2O)CCC=2[C@@]1(C=CC(C2)=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat LD50 subcutaneous 99mg/kg (99mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
women TDLo parenteral 1200ug/kg (1.2mg/kg) MUSCULOSKELETAL: OTHER CHANGES British Journal of Rheumatology. Vol. 34, Pg. 385, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 270 deg C   EXP
log P (octanol-water) 1.16 (none)   EXP
Water Solubility 80 mg/L 25 EXP
Vapor Pressure 7.20E-15 mm Hg 25 EST
Henry's Law Constant 1.97E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.44E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.