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Substance Name: Mefeclorazine [INN:DCF]
RN: 1243-33-0
UNII: IM840F32VV
InChIKey: PJDRMPCBIWKBJA-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H25-Cl-N2-O2

Molecular Weight

  • 360.8825
 
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Names and Synonyms

Name of Substance

  • Mefeclorazine [INN:DCF]

Synonyms

  • 1-(2-Chlorphenyl)-4-(3,4-dimethoxyphenethyl)piperazine
  • 1-o-Chlorophenyl-4-(3,4-dimethoxyphenethyl)piperazine
  • 5-23-02-00160 (Beilstein Handbook Reference)
  • BRN 0627902
  • Mefeclorazina
  • Mefeclorazina [INN-Spanish]
  • Mefeclorazine
  • Mefeclorazinum
  • Mefeclorazinum [INN-Latin]
  • Mepheclorazin
  • N-(Dimethoxy-3,4-phenethyl),-N'-(chloro-2-phenyl) piperazine
  • SD 218-06
  • UNII-IM840F32VV

Systematic Names

  • 1-o-Chlorophenyl-4-(3,4-dimethoxyphenethyl)piperazine
  • Piperazine, 1-(o-chlorophenyl)-4-(3,4-dimethoxyphenethyl)-

Registry Numbers

CAS Registry Number

  • 1243-33-0

FDA UNII

  • IM840F32VV

System Generated Number

  • 0001243330

Structure Descriptors

InChI

1S/C20H25ClN2O2/c1-24-19-8-7-16(15-20(19)25-2)9-10-22-11-13-23(14-12-22)18-6-4-3-5-17(18)21/h3-8,15H,9-14H2,1-2H3

InChIKey

PJDRMPCBIWKBJA-UHFFFAOYSA-N

Smiles

COc1ccc(cc1OC)CCN2CCN(CC2)c3ccccc3Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg) AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR DILATION
Journal of Medicinal Chemistry. Vol. 8, Pg. 104, 1965.
mouse LD50 intravenous 55mg/kg (55mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 133, Pg. 29, 1961.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.