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Substance Name: Hydroxyzine monohydrochloride
RN: 1244-76-4
UNII: CA67JF5Q4W
InChIKey: IPSVAUIEEPSJRZ-UHFFFAOYSA-N

Note

  • A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Molecular Formula

  • C21-H27-Cl-N2-O2.Cl-H

Molecular Weight

  • 411.3702
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Hydroxyzine monohydrochloride

Synonyms

  • 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine hydrochloride
  • EINECS 214-989-3
  • Hydroxyzine HCl
  • Hydroxyzine hydrochloride
  • Hydroxyzine monohydrochloride
  • UNII-CA67JF5Q4W

Systematic Names

  • 2-(2-(4-((4-Chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)ethanol hydrochloride
  • Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 1244-76-4

FDA UNII

  • CA67JF5Q4W

System Generated Number

  • 0001244764

Molecular Formulas

Molecular Formula

  • C21-H27-Cl-N2-O2.Cl-H

Molecular Formula Fragments

  • C21-H27-Cl-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H27ClN2O2.ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;/h1-9,21,25H,10-17H2;1H

InChIKey

IPSVAUIEEPSJRZ-UHFFFAOYSA-N

Smiles

c1ccc(cc1)C(c2ccc(cc2)Cl)N3CCN(CC3)CCOCCO.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 137mg/kg (137mg/kg)   Drugs in Japan Vol. 6, Pg. 621, 1982.
mouse LD50 intravenous 56mg/kg (56mg/kg)   Drugs in Japan Vol. 6, Pg. 621, 1982.
mouse LD50 oral 515mg/kg (515mg/kg) BEHAVIORAL: ANTICONVULSANT Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 49, Pg. 510, 1960.
rat LD50 intraperitoneal 126mg/kg (126mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intravenous 81mg/kg (81mg/kg)   Drugs in Japan Vol. -, Pg. 1009, 1995.
rat LD50 oral 690mg/kg (690mg/kg)   Drugs in Japan Vol. 6, Pg. 621, 1982.