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Substance Name: Losartan potassium [USAN:USP]
RN: 124750-99-8
UNII: 3ST302B24A
InChIKey: OXCMYAYHXIHQOA-UHFFFAOYSA-N

Note

  • An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.

Molecular Formula

  • C22-H23-Cl-N6-O.K

Molecular Weight

  • 461.0078
 

Classification Codes

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin Receptor Antagonists
  • Anti-Arrhythmia AgentsE
  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Losartan potassium [USAN:USP]

Synonyms

  • 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, monopotassium salt
  • 2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5-methanol potassium
  • 2-Butyl-4-chloro-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)imidazole-5-methanol, monopotassium salt
  • Cozaar
  • Du Pont 753
  • DuP 753
  • L-158086
  • Lifezar
  • Lortaan
  • Lorzaan
  • Lorzaar
  • Losacar
  • Losacor
  • Losaprex
  • Losartan potassium
  • Lotim
  • MK 0954
  • MK 954
  • MK-0954
  • MK0954
  • Neo Lotan
  • Niten
  • Ocsaar
  • Tenopres
  • UNII-3ST302B24A

Systematic Name

  • 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, monopotassium salt

Mixture Name

  • Hyzaar

Registry Numbers

CAS Registry Number

  • 124750-99-8

FDA UNII

  • 3ST302B24A

Related Registry Number

  • 114798-26-4 (Parent)

System Generated Number

  • 0124750998

Molecular Formulas

Molecular Formula

  • C22-H23-Cl-N6-O.K

Molecular Formula Fragments

  • C22-H23-Cl-N6-O
  • COMPONENT
  • K

Structure Descriptors

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChIKey

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Smiles

CCCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[n-]nnn4)CO)Cl.[K+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 320mg/kg (320mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
man TDLo oral 10mg/kg/2W-I (10mg/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Archives of Internal Medicine. Vol. 158, Pg. 191, 1998.
mouse LDLo intraperitoneal 400mg/kg (400mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
mouse LDLo intraperitoneal 400mg/kg (400mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
mouse LDLo oral 1gm/kg (1000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
rat LDLo intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
rat LDLo oral 2gm/kg (2000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
women TDLo oral 1mg/kg/1D-I (1mg/kg)   Archives of Internal Medicine. Vol. 158, Pg. 2063, 1998.
women TDLo oral 1mg/kg/1D-I (1mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Archives of Internal Medicine. Vol. 158, Pg. 2063, 1998.