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Substance Name: Tissue inhibitor of metalloproteinase-2
RN: 124861-55-8
InChIKey: ATBAPSKSPYQAEF-LNXGDYIDSA-N

Note

  • A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

Molecular Weight

  • 14054.0706
 

Classification Codes

  • Enzyme Inhibitors
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
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Names and Synonyms

Name of Substance

  • Tissue inhibitor of metalloproteinase-2

MeSH Heading

  • Tissue inhibitor of metalloproteinase-2

Synonyms

  • Timp-2
  • Tissue inhibitor-of metalloproteinase-2

Systematic Name

  • Proteinase inhibitor, TIMP-2

Registry Numbers

CAS Registry Number

  • 124861-55-8

Other Registry Number

  • 127497-59-0

System Generated Number

  • 0124861558

Structure Descriptors

InChI

1S/C619H974N166O189S9/c1-67-311(40)484-595(952)676-322(51)500(857)658-271-451(817)678-357(138-93-106-211-621)515(872)670-324(53)502(859)686-372(185-199-459(825)826)509(866)659-273-454(820)682-409(257-467(841)842)512(869)662-272-452(818)680-359(140-95-108-213-623)520(877)703-387(209-234-977-66)539(896)726-405(251-346-267-651-295-668-346)564(921)772-494(321(50)77-11)605(962)778-498(333(62)798)609(966)737-392(238-300(18)19)548(905)751-431-292-982-983-293-432-580(937)750-427(287-794)614(971)784-230-125-157-437(784)585(942)761-480(307(32)33)590(947)741-417(252-347-268-652-296-669-347)612(969)782-228-123-155-435(782)582(939)705-375(181-195-441(636)807)531(888)695-373(179-193-439(634)805)518(875)672-325(54)503(860)715-395(240-335-127-82-78-83-128-335)553(910)752-430(291-981-980-290-429(577(934)714-388(616(973)974)192-206-466(839)840)684-456(822)276-660-510(867)385(207-232-975-64)702-530(887)374(180-194-440(635)806)699-550(907)397(245-340-161-171-349(801)172-162-340)720-528(885)370(151-119-224-654-618(646)647)694-555(912)404(250-345-266-650-294-667-345)727-557(914)408(255-447(642)813)728-545(902)389(235-297(12)13)718-572(929)422(282-789)744-529(886)365(146-101-114-219-629)689-521(878)361(142-97-110-215-625)690-532(889)376(182-196-442(637)808)713-607(964)497(332(61)797)779-610(967)499(334(63)799)777-576(933)426(286-793)745-547(904)391(237-299(16)17)736-608(965)496(331(60)796)776-569(926)416(264-474(855)856)732-554(911)403(249-344-265-656-355-136-91-90-135-353(344)355)735-583(940)436-156-126-231-785(436)615(972)483(310(38)39)763-604(961)493(320(49)76-10)771-562(919)401(243-338-133-88-81-89-134-338)725-558(915)410(258-468(843)844)734-579(431)936)578(935)729-407(254-446(641)812)544(901)674-326(55)504(861)716-412(260-470(847)848)565(922)760-481(308(34)35)593(950)762-482(309(36)37)594(951)774-492(319(48)75-9)601(958)710-369(150-118-223-653-617(644)645)517(874)671-323(52)501(858)685-360(141-96-109-214-624)516(873)673-327(56)505(862)756-477(304(26)27)591(948)749-424(284-791)571(928)701-379(186-200-460(827)828)533(890)691-363(144-99-112-217-627)523(880)698-383(190-204-464(835)836)541(898)759-479(306(30)31)589(946)740-411(259-469(845)846)559(916)743-419(279-786)513(870)663-274-453(819)681-406(253-445(640)811)556(913)733-415(263-473(853)854)568(925)770-489(316(45)72-6)602(959)738-394(244-339-159-169-348(800)170-160-339)511(868)661-275-455(821)683-418(256-448(643)814)613(970)783-229-124-158-438(783)586(943)773-491(318(47)74-8)600(957)709-366(147-102-115-220-630)524(881)693-371(152-120-225-655-619(648)649)540(897)764-487(314(43)70-4)598(955)711-377(183-197-443(638)809)535(892)721-398(246-341-163-173-350(802)174-164-341)551(908)700-384(191-205-465(837)838)543(900)766-486(313(42)69-3)597(954)707-367(148-103-116-221-631)525(882)696-378(184-198-444(639)810)542(899)765-485(312(41)68-2)596(953)708-368(149-104-117-222-632)526(883)704-386(208-233-976-65)538(895)723-396(241-336-129-84-79-85-130-336)549(906)687-356(137-92-105-210-620)508(865)666-278-458(824)780-226-121-153-433(780)581(938)706-381(188-202-462(831)832)534(891)692-364(145-100-113-218-628)527(884)730-414(262-472(851)852)567(924)769-488(315(44)71-5)599(956)712-382(189-203-463(833)834)537(894)724-400(242-337-131-86-80-87-132-337)561(918)768-490(317(46)73-7)603(960)739-402(248-343-167-177-352(804)178-168-343)563(920)775-495(330(59)795)606(963)677-329(58)611(968)781-227-122-154-434(781)584(941)747-423(283-790)574(931)746-420(280-787)570(927)675-328(57)506(863)757-478(305(28)29)592(949)754-428(289-979-978-288-354(633)507(864)742-421(281-788)575(932)753-432)514(871)664-277-457(823)755-476(303(24)25)588(945)748-425(285-792)573(930)719-390(236-298(14)15)546(903)731-413(261-471(849)850)566(923)758-475(302(22)23)587(944)665-269-449(815)657-270-450(816)679-358(139-94-107-212-622)519(876)688-362(143-98-111-216-626)522(879)697-380(187-201-461(829)830)536(893)722-399(247-342-165-175-351(803)176-166-342)552(909)717-393(239-301(20)21)560(917)767-484/h78-91,127-136,159-178,265-268,294-334,354,356-438,475-499,656,786-804H,67-77,92-126,137-158,179-264,269-293,620-633H2,1-66H3,(H2,634,805)(H2,635,806)(H2,636,807)(H2,637,808)(H2,638,809)(H2,639,810)(H2,640,811)(H2,641,812)(H2,642,813)(H2,643,814)(H,650,667)(H,651,668)(H,652,669)(H,657,815)(H,658,857)(H,659,866)(H,660,867)(H,661,868)(H,662,869)(H,663,870)(H,664,871)(H,665,944)(H,666,865)(H,670,872)(H,671,874)(H,672,875)(H,673,873)(H,674,901)(H,675,927)(H,676,952)(H,677,963)(H,678,817)(H,679,816)(H,680,818)(H,681,819)(H,682,820)(H,683,821)(H,684,822)(H,685,858)(H,686,859)(H,687,906)(H,688,876)(H,689,878)(H,690,889)(H,691,890)(H,692,891)(H,693,881)(H,694,912)(H,695,888)(H,696,882)(H,697,879)(H,698,880)(H,699,907)(H,700,908)(H,701,928)(H,702,887)(H,703,877)(H,704,883)(H,705,939)(H,706,938)(H,707,954)(H,708,953)(H,709,957)(H,710,958)(H,711,955)(H,712,956)(H,713,964)(H,714,934)(H,715,860)(H,716,861)(H,717,909)(H,718,929)(H,719,930)(H,720,885)(H,721,892)(H,722,893)(H,723,895)(H,724,894)(H,725,915)(H,726,896)(H,727,914)(H,728,902)(H,729,935)(H,730,884)(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InChIKey

ATBAPSKSPYQAEF-LNXGDYIDSA-N

Smiles

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