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Substance Name: Tissue inhibitor of metalloproteinase-2
RN: 124861-55-8


  • A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

Classification Codes

  • Enzyme Inhibitors
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
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Names and Synonyms

Name of Substance

  • Tissue inhibitor of metalloproteinase-2

MeSH Heading

  • Tissue inhibitor of metalloproteinase-2


  • Timp-2
  • Tissue inhibitor-of metalloproteinase-2

Systematic Name

  • Proteinase inhibitor, TIMP-2

Registry Numbers

CAS Registry Number

  • 124861-55-8

Other Registry Number

  • 127497-59-0

System Generated Number

  • 0124861558