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Substance Name: Azacosterol hydrochloride [USAN]
RN: 1249-84-9
UNII: B32804UAUQ
InChIKey: BZFBDUQOBQHBSZ-DLCQERRASA-N

Note

  • Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.

Molecular Formula

  • C25-H44-N2-O.2Cl-H

Molecular Weight

  • 461.5574
 

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Anticholesteremic Agents
  • Antimetabolites
  • Chemosterilant, Avian
  • Hypolipidemic Agents
  • Insect Attractant, Repellent and Chemosterilant
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Azacosterol dihydrochloride
  • Azacosterol hydrochloride [USAN]

Synonyms

  • 17-beta-((3-(Dimethylamino)-propyl)methylamino)androst-5-en-3-beta-ol dihydrochloride
  • 17beta-((3-(Dimethylamino)-propyl)methylamino)androst-5-en-3beta-ol dihydrochloride
  • 20,25-Diazacholesterol dihydrochloride
  • AI3-52592
  • Androst-5-en-3-ol, 17-((3-(dimethylamino)propyl)methylamino)-, dihydrochloride, (3beta,17beta)-
  • Azacosterol dihydrochloride
  • Azacosterol HCl
  • Azacosterol hydrochloride
  • Azasterol
  • Caswell No. 286A
  • DiazaCon
  • Diazacosterol hydrochloride
  • EPA Pesticide Chemical Code 098101
  • IMD 760
  • Ornitrol
  • SC 12937
  • SC-12937
  • UNII-B32804UAUQ

Systematic Names

  • Androst-5-en-3-beta-ol, 17-beta-((3-(dimethylamino)propyl)methylamino)-, dihydrochloride
  • Androst-5-en-3-ol, 17-((3-(dimethylamino)propyl)methylamino)-, dihydrochloride, (3beta,17beta)-

Superlist Name

  • 20,25-Diazachlolestenol dihydrochloride

Registry Numbers

CAS Registry Number

  • 1249-84-9

FDA UNII

  • B32804UAUQ

Other Registry Number

  • 1334-33-4

System Generated Number

  • 0001249849

Molecular Formulas

Molecular Formula

  • C25-H44-N2-O.2Cl-H

Molecular Formula Fragments

  • C25-H44-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H44N2O.2ClH/c1-24-13-11-19(28)17-18(24)7-8-20-21-9-10-23(25(21,2)14-12-22(20)24)27(5)16-6-15-26(3)4;;/h7,19-23,28H,6,8-17H2,1-5H3;2*1H/t19-,20-,21-,22-,23-,24-,25-;;/m0../s1

InChIKey

BZFBDUQOBQHBSZ-DLCQERRASA-N

Smiles

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2N(C)CCCN(C)C)CC=C4[C@@]3(CC[C@@H](C4)O)C.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 600mg/kg (600mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C225, 1991.
mouse LD50 intraperitoneal 92mg/kg (92mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C225, 1991.
mouse LD50 oral 380mg/kg (380mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C225, 1991.
rat LD50 intraperitoneal 60mg/kg (60mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C225, 1991.
rat LD50 oral 470mg/kg (470mg/kg)   "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revisionVol. 3, Pg. 100, 1976/1977.