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Substance Name: Prednisolone sodium phosphate [USP:JAN]
RN: 125-02-0
UNII: IV021NXA9J
InChIKey: VJZLQIPZNBPASX-OJJGEMKLSA-L

Note

  • A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Molecular Formula

  • C21-H29-O8-P.2Na

Molecular Weight

  • 484.3903
 

Classification Codes

  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
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Names and Synonyms

Name of Substance

  • Prednisolone sodium phosphate
  • Prednisolone sodium phosphate [USP:JAN]

Synonyms

  • 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate)
  • Codelsol
  • Cortisate-20 (Veterinary)
  • Disodium prednisolone 21-phosphate
  • EINECS 204-722-9
  • Hydeltrasol
  • Inflamase
  • Inflamase Forte
  • Inflamase Mild
  • Metreton
  • Millipred
  • Optival
  • Orapred
  • Orapred ODT
  • Pediapred
  • Phortisolone
  • Predair
  • Predair Forte
  • Prednesol
  • Prednisolone 21-phosphate disodium
  • Prednisolone disodium phosphate
  • Prednisolone sodium phosphate
  • Predsol
  • Predsolan
  • Prozorin
  • Sodium prednisolone phosphate
  • Solucort
  • UNII-IV021NXA9J
  • Veripred 20

Systematic Names

  • Prednisolone 21-(disodium phosphate)
  • Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11beta)-
  • Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt

Superlist Name

  • Prednisolone sodium phosphate

Mixture Names

  • Optimyd
  • Vasocidin Solution

Registry Numbers

CAS Registry Number

  • 125-02-0

FDA UNII

  • IV021NXA9J

System Generated Number

  • 0000125020

Molecular Formulas

Molecular Formula

  • C21-H29-O8-P.2Na

Molecular Formula Fragments

  • C21-H29-O8-P
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1

InChIKey

VJZLQIPZNBPASX-OJJGEMKLSA-L

Smiles

C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=C[C@]34C)O.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LD50 intravenous 360mg/kg (360mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 22, Pg. 1439, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -4.840 (none)   EST
Atmospheric OH Rate Constant 8.42E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.