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Substance Name: Dihydrocodeine [INN:BAN]
RN: 125-28-0
UNII: N9I9HDB855
InChIKey: RBOXVHNMENFORY-DNJOTXNNSA-N

Molecular Formula

  • C18-H23-N-O3

Molecular Weight

  • 301.3837
 

Classification Codes

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Opioid
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Narcotics
  • Peripheral Nervous System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Name of Substance

  • Dihydrocodeine
  • Dihydrocodeine [INN:BAN]
  • Dihydrocodeine [INN]

Synonyms

  • (-)-Dihydrocodeine
  • 3-Methoxy-12-methyl-5,6,7,7a,8,9-hexahydro-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furan-5-ol
  • 6-alpha-Hydrocodol
  • 6-Hydroxy-3-methoxy-N-methyl-4,5-epoxymorphinan
  • 6alpha-Hydrocodol
  • 7,8-Dihydrocodeine
  • 8,14-Dihydroneopine
  • alpha-Hydrocodol
  • Codeine, 7,8-dihydro-
  • Codhydrine
  • Cohydrin
  • Dehacodin
  • Didrate
  • Dihidrocodeina
  • Dihidrocodeina [INN-Spanish]
  • Dihydrin
  • Dihydrocodeine
  • Dihydrocodeinum
  • Dihydrocodeinum [INN-Latin]
  • Dihydrokodein
  • Dihydrokodein [Czech]
  • Dihydroneopine
  • Diidrocodeina
  • Diidrocodeina [DCIT]
  • Drocode
  • EINECS 204-732-3
  • Hydrocodeine
  • Hydrocodin
  • Nadeine
  • Novicodin
  • Novicondin
  • NSC 231319
  • Paracodin
  • Paracodine
  • Parzone
  • Rapacodin
  • UNII-N9I9HDB855

Systematic Names

  • Dihydrocodeine
  • Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-
  • Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
  • Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl-

Superlist Names

  • DEA No. 9120
  • Dihydrocodeine

Mixture Names

  • DHCplus
  • Synalgos-DC

Registry Numbers

CAS Registry Number

  • 125-28-0

FDA UNII

  • N9I9HDB855

System Generated Number

  • 0000125280

Structure Descriptors

InChI

1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

InChIKey

RBOXVHNMENFORY-DNJOTXNNSA-N

Smiles

COc1ccc2C[C@@H]3[C@@H]4CC[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 80mg/kg (80mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
human TDLo oral 6500mg/kg/26W (6500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE		 British Medical Journal. Vol. 1, Pg. 1594, 1978.
man TDLo oral 28mg/kg (28mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 British Medical Journal. Vol. 287, Pg. 751, 1983.
mouse LD50 intravenous 80mg/kg (80mg/kg)   Therapie. Vol. 6, Pg. 146, 1951.
mouse LD50 subcutaneous 135mg/kg (135mg/kg)   Therapie. Vol. 6, Pg. 146, 1951.
rabbit LDLo oral 400mg/kg (400mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
women TDLo subcutaneous 6mg/kg/36H-I (6mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION British Medical Journal. Vol. 1, Pg. 211, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 112.5 deg C   EXP
log P (octanol-water) 1.490 (none)   EST
Atmospheric OH Rate Constant 1.92E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.