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Substance Name: Dihydrocodeine [INN:BAN]
RN: 125-28-0
UNII: N9I9HDB855
InChIKey: RBOXVHNMENFORY-DNJOTXNNSA-N
Molecular Formula
- C18-H23-N-O3
Molecular Weight
- 301.3837
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Opioid
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Narcotics
- Peripheral Nervous System Agents
- Sensory System Agents
Superlist Classification Code
- DEA Schedule II
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Names and Synonyms
Results Name
- Dihydrocodeine [INN:BAN]
Name of Substance
- Dihydrocodeine
- Dihydrocodeine [INN:BAN]
- Dihydrocodeine [INN]
Synonyms
- (-)-Dihydrocodeine
- 3-Methoxy-12-methyl-5,6,7,7a,8,9-hexahydro-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furan-5-ol
- 6-alpha-Hydrocodol
- 6-Hydroxy-3-methoxy-N-methyl-4,5-epoxymorphinan
- 6alpha-Hydrocodol
- 7,8-Dihydrocodeine
- 8,14-Dihydroneopine
- alpha-Hydrocodol
- Codeine, 7,8-dihydro-
- Codhydrine
- Cohydrin
- Dehacodin
- Didrate
- Dihidrocodeina
- Dihidrocodeina [INN-Spanish]
- Dihydrin
- Dihydrocodeine
- Dihydrocodeinum
- Dihydrocodeinum [INN-Latin]
- Dihydrokodein
- Dihydrokodein [Czech]
- Dihydroneopine
- Diidrocodeina
- Diidrocodeina [DCIT]
- Drocode
- EINECS 204-732-3
- Hydrocodeine
- Hydrocodin
- Nadeine
- Novicodin
- Novicondin
- NSC 231319
- Paracodin
- Paracodine
- Parzone
- Rapacodin
- UNII-N9I9HDB855
Systematic Names
- Dihydrocodeine
- Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-
- Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
- Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl-
Superlist Names
- DEA No. 9120
- Dihydrocodeine
Mixture Names
- DHCplus
- Synalgos-DC
Registry Numbers
CAS Registry Number
- 125-28-0
FDA UNII
- N9I9HDB855
System Generated Number
- 0000125280
Structure Descriptors
InChI
InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1InChIKey
RBOXVHNMENFORY-DNJOTXNNSA-NSmiles
COc1ccc2C[C@@H]3[C@@H]4CC[C@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | subcutaneous | 80mg/kg (80mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
human | TDLo | oral | 6500mg/kg/26W (6500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE | British Medical Journal. Vol. 1, Pg. 1594, 1978. |
man | TDLo | oral | 28mg/kg (28mg/kg) | BEHAVIORAL: SLEEP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | British Medical Journal. Vol. 287, Pg. 751, 1983. |
mouse | LD50 | intravenous | 80mg/kg (80mg/kg) | Therapie. Vol. 6, Pg. 146, 1951. | |
mouse | LD50 | subcutaneous | 135mg/kg (135mg/kg) | Therapie. Vol. 6, Pg. 146, 1951. | |
rabbit | LDLo | oral | 400mg/kg (400mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
women | TDLo | subcutaneous | 6mg/kg/36H-I (6mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | British Medical Journal. Vol. 1, Pg. 211, 1959. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 112.5 | deg C | EXP | |
log P (octanol-water) | 1.490 | (none) | EST | |
Atmospheric OH Rate Constant | 1.92E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.