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Substance Name: Hydrocodone [INN:BAN]
RN: 125-29-1
UNII: 6YKS4Y3WQ7
InChIKey: LLPOLZWFYMWNKH-CMKMFDCUSA-N

Note

  • Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.

Molecular Formula

  • C18-H21-N-O3

Molecular Weight

  • 299.3679
 

Classification Codes

Classification Codes

  • Analgesics
  • Analgesics, Opioid
  • Antitussive Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Narcotics
  • Peripheral Nervous System Agents
  • Respiratory System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule II

Names and Synonyms

Results Name

  • Hydrocodone [INN:BAN]

Name of Substance

  • Hydrocodone
  • Hydrocodone polistirex [USAN]
  • Hydrocodone [INN:BAN]

MeSH Heading

  • Hydrocodone

Synonyms

  • (-)-Dihydrocodeinone
  • 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • 4-27-00-03580 (Beilstein Handbook Reference)
  • 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan
  • Bekadid
  • BRN 0094193
  • Codeinone, dihydro-
  • Codinovo
  • DICO
  • Dicodid
  • Dihydrocodeinone
  • EINECS 204-733-9
  • Hidrocodona
  • Hidrocodona [INN-Spanish]
  • HSDB 3097
  • Hydrocodon
  • Hydrocodone
  • Hydrocodone polistirex
  • Hydrocodonum
  • Hydrocodonum [INN-Latin]
  • Hydrocone
  • Hydroconum
  • Idrocodone
  • Idrocodone [DCIT]
  • Multacodin
  • NSC 19044
  • UNII-6YKS4Y3WQ7

Systematic Names

  • Hydrocodone
  • Morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)- (9CI)
  • Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl- (8CI)

Superlist Names

  • DEA No. 9193
  • Hydrocodone

Registry Numbers

CAS Registry Number

  • 125-29-1

FDA UNII

  • 6YKS4Y3WQ7

Other Registry Numbers

  • 1037-91-8
  • 1469752-80-4
  • 50678-79-0
  • 9007-52-7

Related Registry Number

  • 34195-34-1 (tartrate (1:1), hydrate (2:5))

System Generated Number

  • 0000125291

Structure Descriptors

InChI

InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1

InChIKey

LLPOLZWFYMWNKH-CMKMFDCUSA-N

Smiles

COc1ccc2C[C@@H]3[C@@H]4CCC(=O)[C@@H]5Oc1c2[C@]45CCN3C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 9mg/kg (9mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ANALGESIA		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
mouse LD50 subcutaneous 86mg/kg (86mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 52, Pg. 468, 1934.
rabbit LDLo intravenous 7mg/kg (7mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ANALGESIA		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
rat LD50 subcutaneous 150mg/kg (150mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 238, 1953.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 198 deg C   EXP
log P (octanol-water) 2.160 (none)   EST
Water Solubility 6870 mg/L 25 EST
Vapor Pressure 2.83E-07 mm Hg 25 EST
Henry's Law Constant 6.37E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.80E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.