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Substance Name: Ethylmorphine hydrochloride [JAN:NF]
RN: 125-30-4
UNII: MFM5450P3T
InChIKey: ZPPBASOODYCKDP-YZZSNFJZSA-N

Note

  • A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.

Molecular Formula

  • C19-H23-N-O3.Cl-H

Molecular Weight

  • 349.8556
 
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Names and Synonyms

Name of Substance

  • Ethylmorphine hydrochloride [JAN:NF]

Synonyms

  • Codethyline hydrochloride
  • Dionin hydrochloride
  • Dionine hydrochloride
  • EINECS 204-734-4
  • Ethylmorphine HCl
  • Ethylmorphine hydrochloride
  • O-Ethylmorphine hydrochloride
  • UNII-MFM5450P3T

Systematic Names

  • 3-O-Ethylmorphine hydrochloride
  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-ethoxy-17-methyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 125-30-4

FDA UNII

  • MFM5450P3T

System Generated Number

  • 0000125304

Molecular Formulas

Molecular Formula

  • C19-H23-N-O3.Cl-H

Molecular Formula Fragments

  • C19-H23-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H23NO3.ClH/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18;/h4-7,12-14,18,21H,3,8-10H2,1-2H3;1H/t12-,13+,14-,18-,19-;/m0./s1

InChIKey

ZPPBASOODYCKDP-YZZSNFJZSA-N

Smiles

Cl.CCOc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 771mg/kg (771mg/kg)   Annales Pharmaceutiques Francaises. Vol. 15, Pg. 640, 1957.
mouse LD50 subcutaneous 265mg/kg (265mg/kg)   Annales Pharmaceutiques Francaises. Vol. 15, Pg. 640, 1957.
rat LD50 subcutaneous 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 727, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.690 (none)   EST
Water Solubility 2080 mg/L 25 EXP
Vapor Pressure 4.20E-16 mm Hg 25 EST
Henry's Law Constant 5.73E-21 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.32E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.