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Substance Name: Oxyphencyclimine hydrochloride [USP:JAN]
RN: 125-52-0
UNII: GWO1432WOU
InChIKey: WXAYTPABEADAAB-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H28-N2-O3.Cl-H

Molecular Weight

  • 380.9131
 
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Names and Synonyms

Name of Substance

  • Oxyphencyclimine hydrochloride
  • Oxyphencyclimine hydrochloride [USP:JAN]

Synonyms

  • (1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinyl)methyl alpha-phenylcyclohexaneglycolate monohydrochloride
  • 1-Methyl-1,4,5,6-tetrahydro-2-pyrimidylmethyl-alpha-cyclohexyl-phenylglycolate hydrochloride
  • Cycmin
  • Daricon
  • Dominil
  • EINECS 204-742-8
  • Enterex
  • Gastrix
  • Manir
  • NSC 528449
  • Oximin
  • Oxyphencyclimine HCl
  • Oxyphencyclimine hydrochloride
  • S 1-1236
  • Setrol
  • Spazamin
  • Syklifen
  • Ulcociclinina
  • UNII-GWO1432WOU
  • Vagogastrin
  • Vio-Thene
  • W-T Anticholinergic

Systematic Names

  • Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester monohydrochloride
  • Cyclohexaneglycolic acid, alpha-phenyl-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester, monohydrochloride
  • Oxyphencyclimine hydrochloride

Mixture Name

  • Vistrax

Registry Numbers

CAS Registry Number

  • 125-52-0

FDA UNII

  • GWO1432WOU

Other Registry Number

  • 21609-10-9

Related Registry Number

  • 125-53-1 (Parent)

System Generated Number

  • 0000125520

Molecular Formulas

Molecular Formula

  • C20-H28-N2-O3.Cl-H

Molecular Formula Fragments

  • C20-H28-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H28N2O3.ClH/c1-22-14-8-13-21-18(22)15-25-19(23)20(24,16-9-4-2-5-10-16)17-11-6-3-7-12-17;/h2,4-5,9-10,17,24H,3,6-8,11-15H2,1H3;1H

InChIKey

WXAYTPABEADAAB-UHFFFAOYSA-N

Smiles

CN1CCCN=C1COC(=O)C(c2ccccc2)(C3CCCCC3)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 47mg/kg (47mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
dog LD50 oral 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

CARDIAC: CHANGE IN RATE

BEHAVIORAL: TREMOR
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
mouse LD50 intramuscular 210mg/kg (210mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
mouse LD50 intravenous 80mg/kg (80mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
mouse LD50 oral 860mg/kg (860mg/kg)   Drugs in Japan Vol. 6, Pg. 152, 1982.
mouse LD50 subcutaneous 335mg/kg (335mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
rat LD50 intramuscular 1050mg/kg (1050mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
rat LD50 intraperitoneal 130mg/kg (130mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
rat LD50 intravenous 88mg/kg (88mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
rat LD50 oral 1370mg/kg (1370mg/kg)   Drugs in Japan Vol. 6, Pg. 152, 1982.
rat LD50 subcutaneous 1150mg/kg (1150mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.