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Substance Name: Levomethorphan hydrobromide
RN: 125-68-8
UNII: 9YNW43KIJI
InChIKey: MISZALMBODQYFT-FLCXFYETSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H25-N-O.Br-H

Molecular Weight

  • 352.313
 
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Names and Synonyms

Name of Substance

  • Levomethorphan hydrobromide

Synonyms

  • 3-Methoxy-17-methylmorphinan hydrobromide
  • Levomethorphan hydrobromide
  • Ro 1-5470/6
  • Ro 1-7788
  • UNII-9YNW43KIJI

Systematic Name

  • Morphinan, 3-methoxy-17-methyl-, hydrobromide

Registry Numbers

CAS Registry Number

  • 125-68-8

FDA UNII

  • 9YNW43KIJI

System Generated Number

  • 0000125688

Molecular Formulas

Molecular Formula

  • C18-H25-N-O.Br-H

Molecular Formula Fragments

  • Br-H
  • C18-H25-N-O
  • COMPONENT

Structure Descriptors

InChI

1S/C18H25NO.BrH/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H/t15-,17+,18+;/m0./s1

InChIKey

MISZALMBODQYFT-FLCXFYETSA-N

Smiles

C1CCC[C@]23c4cc(ccc4C[C@H]([N@@](C)CC3)[C@H]12)OC.Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 31mg/kg (31mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 oral 145mg/kg (145mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 subcutaneous 103mg/kg (103mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rabbit LD50 intravenous 11500ug/kg (11.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 oral 242mg/kg (242mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 subcutaneous 363mg/kg (363mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.