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Substance Name: Gestonorone caproate [USAN:INN:JAN]
RN: 1253-28-7
UNII: U38E620NS6
InChIKey: XURCMZMFZXXQDJ-UKNJCJGYSA-N

Note

  • A long-acting potent progestogen structurally related to PROGESTERONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1185)

Molecular Formula

  • C26-H38-O4

Molecular Weight

  • 414.5822
 

Classification Codes

  • Drug / Therapeutic Agent
  • Progestin
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Names and Synonyms

Results Name

  • Gestonorone caproate [USAN:INN:JAN]

Name of Substance

  • Gestonorone caproate
  • Gestonorone caproate [USAN:INN:JAN]

MeSH Heading

  • Gestonorone caproate

Synonyms

  • 17-((1-Oxohexyl)oxy)-19-norpregn-4-ene-3,20-dione
  • 17-alpha-Hexanoyloxy-19-nor-4-pregnene-3,20-dione
  • 17-alpha-Hydroxy-19-norprogesterone caproate
  • 17-beta-Acetyl-17-hydroxyestr-4-ene-3-one hexanoate
  • 17-Hydroxy-19-norpregn-4-ene-3,20-dione hexanoate
  • 17alpha-Hydroxy-19-norprogesterone caproate
  • 17alpha-Hydroxy-19-norprogesterone capronate
  • 17alpha-Hydroxy-19norprogesterone-17alpha caproate
  • 19-Nor-17alpha-hydroxyprogesterone caproate
  • 19-Norpregn-4-ene-3,20-dione, 17-((1-oxohexyl)oxy)-
  • 19-Norprogesterone, 17-hydroxy-, hexanoate
  • Caproate de gestonorone
  • Caproate de gestonorone [INN-French]
  • Caproato de gestonorona
  • Caproato de gestonorona [INN-Spanish]
  • CCRIS 6524
  • Depostat
  • EINECS 215-010-2
  • Gestonorone caproate
  • Gestonorone capronate
  • Gestonoroni caproas
  • Gestonoroni caproas [INN-Latin]
  • Gestronol caproate
  • Gestronol hexanoate
  • NSC 84054
  • Primostat
  • SH 582
  • SH 80582
  • UNII-U38E620NS6

Systematic Names

  • 19-Norpregn-4-ene-3,20-dione, 17-((1-oxohexyl)oxy)-
  • 19-Norpregn-4-ene-3,20-dione, 17-hydroxy-, hexanoate
  • Gestonorone caproate

Registry Numbers

CAS Registry Number

  • 1253-28-7

FDA UNII

  • U38E620NS6

System Generated Number

  • 0001253287

Structure Descriptors

InChI

1S/C26H38O4/c1-4-5-6-7-24(29)30-26(17(2)27)15-13-23-22-10-8-18-16-19(28)9-11-20(18)21(22)12-14-25(23,26)3/h16,20-23H,4-15H2,1-3H3/t20-,21+,22+,23-,25-,26-/m0/s1

InChIKey

XURCMZMFZXXQDJ-UKNJCJGYSA-N

Smiles

CCCCCC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular > 150mg/kg (150mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
mouse LD50 intraperitoneal > 10gm/kg (10000mg/kg) LIVER: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 296, 1977.
mouse LD50 oral > 10gm/kg (10000mg/kg) LIVER: OTHER CHANGES Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 296, 1977.
mouse LD50 subcutaneous 10gm/kg (10000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 intramuscular 400mg/kg (400mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 296, 1977.
rat LD50 intraperitoneal 6800mg/kg (6800mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg) GASTROINTESTINAL: OTHER CHANGES Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 296, 1977.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 296, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 123.5 deg C   EXP
log P (octanol-water) 5.180 (none)   EST
Atmospheric OH Rate Constant 1.10E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.