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Substance Name: Netarsudil [USAN]
RN: 1254032-66-0
UNII: W6I5QDT7QI
InChIKey: OURRXQUGYQRVML-AREMUKBSSA-N

Note

  • A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous.

Molecular Formula

  • C28-H27-N3-O3

Molecular Weight

  • 453.5393
 
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Names and Synonyms

Results Name

  • Netarsudil [USAN]

Name of Substance

  • Netarsudil

Synonyms

  • (4-((1S)-1-(Aminomethyl)-2-(isoquinolin-6-ylamino)-2-oxoethyl)phenyl)methyl 2,4- dimethylbenzoate
  • AR-11324 free base
  • AR-13324
  • Benzoic acid, 2,4-dimethyl-, (4-((1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl)phenyl)methyl ester
  • Netarsudil
  • Netarsudil [USAN]
  • Rhopressa
  • UNII-W6I5QDT7QI

Registry Numbers

CAS Registry Number

  • 1254032-66-0

FDA UNII

  • W6I5QDT7QI

Other Registry Number

  • 1628418-15-4

System Generated Number

  • 1254032660

Structure Descriptors

InChI

1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)/t26-/m1/s1

InChIKey

OURRXQUGYQRVML-AREMUKBSSA-N

Smiles

Cc1ccc(C(=O)OCc2ccc(cc2)[C@@H](CN)C(=O)Nc3ccc4cnccc4c3)c(C)c1