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Substance Name: Gilteritinib [USAN:INN]
RN: 1254053-43-4
UNII: 66D92MGC8M
InChIKey: GYQYAJJFPNQOOW-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and anaplastic lymphoma kinase (ALK or CD246), with potential antineoplastic activity. Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction pathways and reduction of tumor cell proliferation in cancer cell types that overexpress these RTKs. FLT3, AXL and ALK, overexpressed or mutated in a variety of cancer cell types, play a key role in tumor cell growth and survival. (NCI Thesaurus)

Molecular Formula

  • C29-H44-N8-O3

Molecular Weight

  • 552.7196
 

Classification Code

  • Treatment of Acute Myeloid Leukemia
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Names and Synonyms

Name of Substance

  • Gilteritinib [USAN:INN]

Synonyms

  • 2-Pyrazinecarboxamide, 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-
  • ASP 2215
  • ASP2215
  • Gilteritinib
  • UNII-66D92MGC8M

Registry Numbers

CAS Registry Number

  • 1254053-43-4

FDA UNII

  • 66D92MGC8M

System Generated Number

  • 1254053434

Structure Descriptors

InChI

1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

InChIKey

GYQYAJJFPNQOOW-UHFFFAOYSA-N

Smiles

CCc1c(nc(c(n1)C(=O)N)Nc2ccc(c(c2)OC)N3CCC(CC3)N4CCN(CC4)C)NC5CCOCC5